Cargando…
miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3
Pancreatic cancer cells are characterized by high cell proliferation and low cell apoptosis, but the factors involved in these processes remain to be further studied. In this study, we report that miR-324-5p regulates the proliferation and apoptosis of pancreatic cancer cells through regulating the...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452094/ https://www.ncbi.nlm.nih.gov/pubmed/32913892 http://dx.doi.org/10.1016/j.omto.2020.07.011 |
_version_ | 1783575106948169728 |
---|---|
author | Wan, Yiyuan Luo, Hesheng Yang, Ming Tian, Xia Peng, Bo Zhan, Ting Chen, Xiaoli Ding, Yu He, Jinrong Cheng, Xueting Huang, Xiaodong Zhang, Yadong |
author_facet | Wan, Yiyuan Luo, Hesheng Yang, Ming Tian, Xia Peng, Bo Zhan, Ting Chen, Xiaoli Ding, Yu He, Jinrong Cheng, Xueting Huang, Xiaodong Zhang, Yadong |
author_sort | Wan, Yiyuan |
collection | PubMed |
description | Pancreatic cancer cells are characterized by high cell proliferation and low cell apoptosis, but the factors involved in these processes remain to be further studied. In this study, we report that miR-324-5p regulates the proliferation and apoptosis of pancreatic cancer cells through regulating the expression of Krüppel-like factor 3 (KLF3). In both pancreatic cancer tissues and cell lines, the levels of miR-324-5p are significantly increased. Inhibition of miR-324-5p represses cell proliferation but promotes cell apoptosis, whereas overexpression of miR-324-5p exerts the opposite effect. Furthermore, we identified KLF3, a factor regulating pancreatic cancer cell proliferation and apoptosis, as a new direct downstream target of miR-324-5p. Our results suggest that miR-324-5p plays an important role in pancreatic cancer cell proliferation and apoptosis via downregulating the expression of KLF3. |
format | Online Article Text |
id | pubmed-7452094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Society of Gene & Cell Therapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-74520942020-09-09 miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3 Wan, Yiyuan Luo, Hesheng Yang, Ming Tian, Xia Peng, Bo Zhan, Ting Chen, Xiaoli Ding, Yu He, Jinrong Cheng, Xueting Huang, Xiaodong Zhang, Yadong Mol Ther Oncolytics Article Pancreatic cancer cells are characterized by high cell proliferation and low cell apoptosis, but the factors involved in these processes remain to be further studied. In this study, we report that miR-324-5p regulates the proliferation and apoptosis of pancreatic cancer cells through regulating the expression of Krüppel-like factor 3 (KLF3). In both pancreatic cancer tissues and cell lines, the levels of miR-324-5p are significantly increased. Inhibition of miR-324-5p represses cell proliferation but promotes cell apoptosis, whereas overexpression of miR-324-5p exerts the opposite effect. Furthermore, we identified KLF3, a factor regulating pancreatic cancer cell proliferation and apoptosis, as a new direct downstream target of miR-324-5p. Our results suggest that miR-324-5p plays an important role in pancreatic cancer cell proliferation and apoptosis via downregulating the expression of KLF3. American Society of Gene & Cell Therapy 2020-07-31 /pmc/articles/PMC7452094/ /pubmed/32913892 http://dx.doi.org/10.1016/j.omto.2020.07.011 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wan, Yiyuan Luo, Hesheng Yang, Ming Tian, Xia Peng, Bo Zhan, Ting Chen, Xiaoli Ding, Yu He, Jinrong Cheng, Xueting Huang, Xiaodong Zhang, Yadong miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3 |
title | miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3 |
title_full | miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3 |
title_fullStr | miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3 |
title_full_unstemmed | miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3 |
title_short | miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3 |
title_sort | mir-324-5p contributes to cell proliferation and apoptosis in pancreatic cancer by targeting klf3 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452094/ https://www.ncbi.nlm.nih.gov/pubmed/32913892 http://dx.doi.org/10.1016/j.omto.2020.07.011 |
work_keys_str_mv | AT wanyiyuan mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 AT luohesheng mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 AT yangming mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 AT tianxia mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 AT pengbo mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 AT zhanting mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 AT chenxiaoli mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 AT dingyu mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 AT hejinrong mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 AT chengxueting mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 AT huangxiaodong mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 AT zhangyadong mir3245pcontributestocellproliferationandapoptosisinpancreaticcancerbytargetingklf3 |