Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy

To enhance human prostate-specific membrane antigen (hPSMA)-specific chimeric antigen receptor (CAR) T cell therapy in a hPSMA(+) MyC-CaP tumor model, we studied and imaged the effect of lactate dehydrogenase A (LDH-A) depletion on the tumor microenvironment (TME) and tumor progression. Effective LD...

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Detalles Bibliográficos
Autores principales: Mane, Mayuresh M., Cohen, Ivan J., Ackerstaff, Ellen, Shalaby, Khalid, Ijoma, Jenny N., Ko, Myat, Maeda, Masatomo, Albeg, Avi S., Vemuri, Kiranmayi, Satagopan, Jaya, Moroz, Anna, Zurita, Juan, Shenker, Larissa, Shindo, Masahiro, Nickles, Tanner, Nikolov, Ekaterina, Moroz, Maxim A., Koutcher, Jason A., Serganova, Inna, Ponomarev, Vladimir, Blasberg, Ronald G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452096/
https://www.ncbi.nlm.nih.gov/pubmed/32913888
http://dx.doi.org/10.1016/j.omto.2020.07.006

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