Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

Cellular iron, at the physiological level, is essential to maintain several metabolic pathways, while an excess of free iron may cause oxidative damage and/or provoke cell death. Consequently, iron homeostasis has to be tightly controlled. Under hypoxia these regulatory mechanisms for human macropha...

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Detalles Bibliográficos
Autores principales: Fuhrmann, Dominik C., Mondorf, Antonia, Beifuß, Josefine, Jung, Michaela, Brüne, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452134/
https://www.ncbi.nlm.nih.gov/pubmed/32810738
http://dx.doi.org/10.1016/j.redox.2020.101670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452134/
https://www.ncbi.nlm.nih.gov/pubmed/32810738
http://dx.doi.org/10.1016/j.redox.2020.101670

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