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Cholinergic Modulation of the Default Mode Like Network in Rats
The discovery of the default mode network (DMN), a large-scale brain network that is suppressed during attention-demanding tasks, had major impact in neuroscience. This network exhibits an antagonistic relationship with attention-related networks. A better understanding of the processes underlying m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452182/ https://www.ncbi.nlm.nih.gov/pubmed/32846343 http://dx.doi.org/10.1016/j.isci.2020.101455 |
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author | Peeters, Lore M. van den Berg, Monica Hinz, Rukun Majumdar, Gaurav Pintelon, Isabel Keliris, Georgios A. |
author_facet | Peeters, Lore M. van den Berg, Monica Hinz, Rukun Majumdar, Gaurav Pintelon, Isabel Keliris, Georgios A. |
author_sort | Peeters, Lore M. |
collection | PubMed |
description | The discovery of the default mode network (DMN), a large-scale brain network that is suppressed during attention-demanding tasks, had major impact in neuroscience. This network exhibits an antagonistic relationship with attention-related networks. A better understanding of the processes underlying modulation of DMN is imperative, as this network is compromised in several neurological diseases. Cholinergic neuromodulation is one of the major regulatory networks for attention, and studies suggest a role in regulation of the DMN. In this study, we unilaterally activated the right basal forebrain cholinergic neurons and observed decreased right intra-hemispheric and interhemispheric FC in the default mode like network (DMLN). Our findings provide critical insights into the interplay between cholinergic neuromodulation and DMLN, demonstrate that differential effects can be exerted between the two hemispheres by unilateral stimulation, and open windows for further studies involving directed modulations of DMN in treatments for diseases demonstrating compromised DMN activity. |
format | Online Article Text |
id | pubmed-7452182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74521822020-08-31 Cholinergic Modulation of the Default Mode Like Network in Rats Peeters, Lore M. van den Berg, Monica Hinz, Rukun Majumdar, Gaurav Pintelon, Isabel Keliris, Georgios A. iScience Article The discovery of the default mode network (DMN), a large-scale brain network that is suppressed during attention-demanding tasks, had major impact in neuroscience. This network exhibits an antagonistic relationship with attention-related networks. A better understanding of the processes underlying modulation of DMN is imperative, as this network is compromised in several neurological diseases. Cholinergic neuromodulation is one of the major regulatory networks for attention, and studies suggest a role in regulation of the DMN. In this study, we unilaterally activated the right basal forebrain cholinergic neurons and observed decreased right intra-hemispheric and interhemispheric FC in the default mode like network (DMLN). Our findings provide critical insights into the interplay between cholinergic neuromodulation and DMLN, demonstrate that differential effects can be exerted between the two hemispheres by unilateral stimulation, and open windows for further studies involving directed modulations of DMN in treatments for diseases demonstrating compromised DMN activity. Elsevier 2020-08-12 /pmc/articles/PMC7452182/ /pubmed/32846343 http://dx.doi.org/10.1016/j.isci.2020.101455 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Peeters, Lore M. van den Berg, Monica Hinz, Rukun Majumdar, Gaurav Pintelon, Isabel Keliris, Georgios A. Cholinergic Modulation of the Default Mode Like Network in Rats |
title | Cholinergic Modulation of the Default Mode Like Network in Rats |
title_full | Cholinergic Modulation of the Default Mode Like Network in Rats |
title_fullStr | Cholinergic Modulation of the Default Mode Like Network in Rats |
title_full_unstemmed | Cholinergic Modulation of the Default Mode Like Network in Rats |
title_short | Cholinergic Modulation of the Default Mode Like Network in Rats |
title_sort | cholinergic modulation of the default mode like network in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452182/ https://www.ncbi.nlm.nih.gov/pubmed/32846343 http://dx.doi.org/10.1016/j.isci.2020.101455 |
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