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Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success

Preclinical large animal models of heart failure (HF) play a critical and expanding role in translating basic science findings to the development and clinical approval of novel therapeutics and devices. The complex combination of cardiovascular events and risk factors leading to HF has proved challe...

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Detalles Bibliográficos
Autores principales: Silva, Kleiton Augusto Santos, Emter, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452204/
https://www.ncbi.nlm.nih.gov/pubmed/32875172
http://dx.doi.org/10.1016/j.jacbts.2020.04.011
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author Silva, Kleiton Augusto Santos
Emter, Craig A.
author_facet Silva, Kleiton Augusto Santos
Emter, Craig A.
author_sort Silva, Kleiton Augusto Santos
collection PubMed
description Preclinical large animal models of heart failure (HF) play a critical and expanding role in translating basic science findings to the development and clinical approval of novel therapeutics and devices. The complex combination of cardiovascular events and risk factors leading to HF has proved challenging for the development of new treatments for these patients. This state-of-the-art review presents historical and recent studies in porcine, ovine, and canine models of HF and outlines existing methodologies and physiological phenotypes. The translational importance of large animal studies to clinical success is also highlighted with an overview of recent devices approved by the Food and Drug Administration, together with preclinical HF animal studies used to aid both development and safety and/or efficacy testing. Increasing the use of large animal models of HF holds significant potential for identifying the novel mechanisms underlying the clinical condition and to improving physiological and economical translation of animal research to successfully treat human HF.
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spelling pubmed-74522042020-08-31 Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success Silva, Kleiton Augusto Santos Emter, Craig A. JACC Basic Transl Sci STATE-OF-THE-ART REVIEW Preclinical large animal models of heart failure (HF) play a critical and expanding role in translating basic science findings to the development and clinical approval of novel therapeutics and devices. The complex combination of cardiovascular events and risk factors leading to HF has proved challenging for the development of new treatments for these patients. This state-of-the-art review presents historical and recent studies in porcine, ovine, and canine models of HF and outlines existing methodologies and physiological phenotypes. The translational importance of large animal studies to clinical success is also highlighted with an overview of recent devices approved by the Food and Drug Administration, together with preclinical HF animal studies used to aid both development and safety and/or efficacy testing. Increasing the use of large animal models of HF holds significant potential for identifying the novel mechanisms underlying the clinical condition and to improving physiological and economical translation of animal research to successfully treat human HF. Elsevier 2020-08-24 /pmc/articles/PMC7452204/ /pubmed/32875172 http://dx.doi.org/10.1016/j.jacbts.2020.04.011 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle STATE-OF-THE-ART REVIEW
Silva, Kleiton Augusto Santos
Emter, Craig A.
Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success
title Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success
title_full Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success
title_fullStr Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success
title_full_unstemmed Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success
title_short Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success
title_sort large animal models of heart failure: a translational bridge to clinical success
topic STATE-OF-THE-ART REVIEW
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452204/
https://www.ncbi.nlm.nih.gov/pubmed/32875172
http://dx.doi.org/10.1016/j.jacbts.2020.04.011
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