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Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success
Preclinical large animal models of heart failure (HF) play a critical and expanding role in translating basic science findings to the development and clinical approval of novel therapeutics and devices. The complex combination of cardiovascular events and risk factors leading to HF has proved challe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452204/ https://www.ncbi.nlm.nih.gov/pubmed/32875172 http://dx.doi.org/10.1016/j.jacbts.2020.04.011 |
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author | Silva, Kleiton Augusto Santos Emter, Craig A. |
author_facet | Silva, Kleiton Augusto Santos Emter, Craig A. |
author_sort | Silva, Kleiton Augusto Santos |
collection | PubMed |
description | Preclinical large animal models of heart failure (HF) play a critical and expanding role in translating basic science findings to the development and clinical approval of novel therapeutics and devices. The complex combination of cardiovascular events and risk factors leading to HF has proved challenging for the development of new treatments for these patients. This state-of-the-art review presents historical and recent studies in porcine, ovine, and canine models of HF and outlines existing methodologies and physiological phenotypes. The translational importance of large animal studies to clinical success is also highlighted with an overview of recent devices approved by the Food and Drug Administration, together with preclinical HF animal studies used to aid both development and safety and/or efficacy testing. Increasing the use of large animal models of HF holds significant potential for identifying the novel mechanisms underlying the clinical condition and to improving physiological and economical translation of animal research to successfully treat human HF. |
format | Online Article Text |
id | pubmed-7452204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74522042020-08-31 Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success Silva, Kleiton Augusto Santos Emter, Craig A. JACC Basic Transl Sci STATE-OF-THE-ART REVIEW Preclinical large animal models of heart failure (HF) play a critical and expanding role in translating basic science findings to the development and clinical approval of novel therapeutics and devices. The complex combination of cardiovascular events and risk factors leading to HF has proved challenging for the development of new treatments for these patients. This state-of-the-art review presents historical and recent studies in porcine, ovine, and canine models of HF and outlines existing methodologies and physiological phenotypes. The translational importance of large animal studies to clinical success is also highlighted with an overview of recent devices approved by the Food and Drug Administration, together with preclinical HF animal studies used to aid both development and safety and/or efficacy testing. Increasing the use of large animal models of HF holds significant potential for identifying the novel mechanisms underlying the clinical condition and to improving physiological and economical translation of animal research to successfully treat human HF. Elsevier 2020-08-24 /pmc/articles/PMC7452204/ /pubmed/32875172 http://dx.doi.org/10.1016/j.jacbts.2020.04.011 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | STATE-OF-THE-ART REVIEW Silva, Kleiton Augusto Santos Emter, Craig A. Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success |
title | Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success |
title_full | Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success |
title_fullStr | Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success |
title_full_unstemmed | Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success |
title_short | Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success |
title_sort | large animal models of heart failure: a translational bridge to clinical success |
topic | STATE-OF-THE-ART REVIEW |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452204/ https://www.ncbi.nlm.nih.gov/pubmed/32875172 http://dx.doi.org/10.1016/j.jacbts.2020.04.011 |
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