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Miliary pattern, a classic pulmonary finding of tuberculosis disease

INTRODUCTION: The increase in age of the population and in the use of immunosuppressive treatment makes tuberculosis (TB) with hematogenous or lymphatic dissemination a current problem. METHODS: We collected all the patients diagnosed with tuberculosis with miliary pulmonary pattern at the Santiago...

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Autores principales: Alende-Castro, Vanesa, Macía-Rodríguez, Cristina, Páez-Guillán, Emilio, García-Villafranca, Alba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452224/
https://www.ncbi.nlm.nih.gov/pubmed/32904186
http://dx.doi.org/10.1016/j.jctube.2020.100179
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author Alende-Castro, Vanesa
Macía-Rodríguez, Cristina
Páez-Guillán, Emilio
García-Villafranca, Alba
author_facet Alende-Castro, Vanesa
Macía-Rodríguez, Cristina
Páez-Guillán, Emilio
García-Villafranca, Alba
author_sort Alende-Castro, Vanesa
collection PubMed
description INTRODUCTION: The increase in age of the population and in the use of immunosuppressive treatment makes tuberculosis (TB) with hematogenous or lymphatic dissemination a current problem. METHODS: We collected all the patients diagnosed with tuberculosis with miliary pulmonary pattern at the Santiago de Compostela University Teaching Hospital (NW Spain) from 1 January 2006 to 31 December 2015. RESULTS: A total of 27 patients were included, 70.4% women, with a median age of 69.0 years old. A cause of immunosuppression was observed only in 51.9% of patients. The majority of the cases (65.0%) presented pulmonary affectation. The most frequently isolated species was Mycobacterium tuberculosis (88.9%). Multiresistance to first-line antituberculosis drugs was observed only in 3.7%. 92.6% of the patients received treatment with Isoniazid, Rifampicin and Pyrazinamine, associated in 48.1% of them with Ethambutol. Two patients died during admission and there were no recurrences in the 2-years follow-up. CONCLUSIONS: Miliary tuberculosis remains a current pathology. Most patients do not have a known cause of immunosuppression. The response to the typical treatment is usually good.
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spelling pubmed-74522242020-09-03 Miliary pattern, a classic pulmonary finding of tuberculosis disease Alende-Castro, Vanesa Macía-Rodríguez, Cristina Páez-Guillán, Emilio García-Villafranca, Alba J Clin Tuberc Other Mycobact Dis Article INTRODUCTION: The increase in age of the population and in the use of immunosuppressive treatment makes tuberculosis (TB) with hematogenous or lymphatic dissemination a current problem. METHODS: We collected all the patients diagnosed with tuberculosis with miliary pulmonary pattern at the Santiago de Compostela University Teaching Hospital (NW Spain) from 1 January 2006 to 31 December 2015. RESULTS: A total of 27 patients were included, 70.4% women, with a median age of 69.0 years old. A cause of immunosuppression was observed only in 51.9% of patients. The majority of the cases (65.0%) presented pulmonary affectation. The most frequently isolated species was Mycobacterium tuberculosis (88.9%). Multiresistance to first-line antituberculosis drugs was observed only in 3.7%. 92.6% of the patients received treatment with Isoniazid, Rifampicin and Pyrazinamine, associated in 48.1% of them with Ethambutol. Two patients died during admission and there were no recurrences in the 2-years follow-up. CONCLUSIONS: Miliary tuberculosis remains a current pathology. Most patients do not have a known cause of immunosuppression. The response to the typical treatment is usually good. Elsevier 2020-08-11 /pmc/articles/PMC7452224/ /pubmed/32904186 http://dx.doi.org/10.1016/j.jctube.2020.100179 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Alende-Castro, Vanesa
Macía-Rodríguez, Cristina
Páez-Guillán, Emilio
García-Villafranca, Alba
Miliary pattern, a classic pulmonary finding of tuberculosis disease
title Miliary pattern, a classic pulmonary finding of tuberculosis disease
title_full Miliary pattern, a classic pulmonary finding of tuberculosis disease
title_fullStr Miliary pattern, a classic pulmonary finding of tuberculosis disease
title_full_unstemmed Miliary pattern, a classic pulmonary finding of tuberculosis disease
title_short Miliary pattern, a classic pulmonary finding of tuberculosis disease
title_sort miliary pattern, a classic pulmonary finding of tuberculosis disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452224/
https://www.ncbi.nlm.nih.gov/pubmed/32904186
http://dx.doi.org/10.1016/j.jctube.2020.100179
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