Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-inflammatory Effects through SHIP1/STAT3 Complexes

The anti-inflammatory actions of interleukin-10 (IL10) are thought to be mediated primarily by the STAT3 transcription factor, but pro-inflammatory cytokines such as interleukin-6 (IL6) also act through STAT3. We now report that IL10, but not IL6 signaling, induces formation of a complex between STA...

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Detalles Bibliográficos
Autores principales: Chamberlain, Thomas C., Cheung, Sylvia T., Yoon, Jeff S.J., Ming-Lum, Andrew, Gardill, Bernd R., Shakibakho, Soroush, Dzananovic, Edis, Ban, Fuqiang, Samiea, Abrar, Jawanda, Kamaldeep, Priatel, John, Krystal, Gerald, Ong, Christopher J., Cherkasov, Artem, Andersen, Raymond J., McKenna, Sean A., Van Petegem, Filip, Mui, Alice L-F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452241/
https://www.ncbi.nlm.nih.gov/pubmed/32823063
http://dx.doi.org/10.1016/j.isci.2020.101433

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