Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model

This multidisciplinary work shows the feasibility of replacing the fetal pulmonary valve with a percutaneous, transcatheter, fully biodegradable tissue-engineered heart valve (TEHV), which was studied in vitro through accelerated degradation, mechanical, and hemodynamic testing and in vivo by implan...

Descripción completa

Detalles Bibliográficos
Autores principales: Zakko, Jason, Blum, Kevin M., Drews, Joseph D., Wu, Yen-Lin, Hatoum, Hoda, Russell, Madeleine, Gooden, Shelley, Heitkemper, Megan, Conroy, Olivia, Kelly, John, Carey, Stacey, Sacks, Michael, Texter, Karen, Ragsdale, Ellie, Strainic, James, Bocks, Martin, Wang, Yadong, Dasi, Lakshmi Prasad, Armstrong, Aimee K., Breuer, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452327/
https://www.ncbi.nlm.nih.gov/pubmed/32875171
http://dx.doi.org/10.1016/j.jacbts.2020.06.009
Descripción
Sumario:This multidisciplinary work shows the feasibility of replacing the fetal pulmonary valve with a percutaneous, transcatheter, fully biodegradable tissue-engineered heart valve (TEHV), which was studied in vitro through accelerated degradation, mechanical, and hemodynamic testing and in vivo by implantation into a fetal lamb. The TEHV exhibited only trivial stenosis and regurgitation in vitro and no stenosis in vivo by echocardiogram. Following implantation, the fetus matured and was delivered at term. Replacing a stenotic fetal valve with a functional TEHV has the potential to interrupt the development of single-ventricle heart disease by restoring proper flow through the heart.

Ejemplares similares