Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model

This multidisciplinary work shows the feasibility of replacing the fetal pulmonary valve with a percutaneous, transcatheter, fully biodegradable tissue-engineered heart valve (TEHV), which was studied in vitro through accelerated degradation, mechanical, and hemodynamic testing and in vivo by implan...

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Autores principales: Zakko, Jason, Blum, Kevin M., Drews, Joseph D., Wu, Yen-Lin, Hatoum, Hoda, Russell, Madeleine, Gooden, Shelley, Heitkemper, Megan, Conroy, Olivia, Kelly, John, Carey, Stacey, Sacks, Michael, Texter, Karen, Ragsdale, Ellie, Strainic, James, Bocks, Martin, Wang, Yadong, Dasi, Lakshmi Prasad, Armstrong, Aimee K., Breuer, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452327/
https://www.ncbi.nlm.nih.gov/pubmed/32875171
http://dx.doi.org/10.1016/j.jacbts.2020.06.009
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author Zakko, Jason
Blum, Kevin M.
Drews, Joseph D.
Wu, Yen-Lin
Hatoum, Hoda
Russell, Madeleine
Gooden, Shelley
Heitkemper, Megan
Conroy, Olivia
Kelly, John
Carey, Stacey
Sacks, Michael
Texter, Karen
Ragsdale, Ellie
Strainic, James
Bocks, Martin
Wang, Yadong
Dasi, Lakshmi Prasad
Armstrong, Aimee K.
Breuer, Christopher
author_facet Zakko, Jason
Blum, Kevin M.
Drews, Joseph D.
Wu, Yen-Lin
Hatoum, Hoda
Russell, Madeleine
Gooden, Shelley
Heitkemper, Megan
Conroy, Olivia
Kelly, John
Carey, Stacey
Sacks, Michael
Texter, Karen
Ragsdale, Ellie
Strainic, James
Bocks, Martin
Wang, Yadong
Dasi, Lakshmi Prasad
Armstrong, Aimee K.
Breuer, Christopher
author_sort Zakko, Jason
collection PubMed
description This multidisciplinary work shows the feasibility of replacing the fetal pulmonary valve with a percutaneous, transcatheter, fully biodegradable tissue-engineered heart valve (TEHV), which was studied in vitro through accelerated degradation, mechanical, and hemodynamic testing and in vivo by implantation into a fetal lamb. The TEHV exhibited only trivial stenosis and regurgitation in vitro and no stenosis in vivo by echocardiogram. Following implantation, the fetus matured and was delivered at term. Replacing a stenotic fetal valve with a functional TEHV has the potential to interrupt the development of single-ventricle heart disease by restoring proper flow through the heart.
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spelling pubmed-74523272020-08-31 Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model Zakko, Jason Blum, Kevin M. Drews, Joseph D. Wu, Yen-Lin Hatoum, Hoda Russell, Madeleine Gooden, Shelley Heitkemper, Megan Conroy, Olivia Kelly, John Carey, Stacey Sacks, Michael Texter, Karen Ragsdale, Ellie Strainic, James Bocks, Martin Wang, Yadong Dasi, Lakshmi Prasad Armstrong, Aimee K. Breuer, Christopher JACC Basic Transl Sci PRECLINICAL RESEARCH This multidisciplinary work shows the feasibility of replacing the fetal pulmonary valve with a percutaneous, transcatheter, fully biodegradable tissue-engineered heart valve (TEHV), which was studied in vitro through accelerated degradation, mechanical, and hemodynamic testing and in vivo by implantation into a fetal lamb. The TEHV exhibited only trivial stenosis and regurgitation in vitro and no stenosis in vivo by echocardiogram. Following implantation, the fetus matured and was delivered at term. Replacing a stenotic fetal valve with a functional TEHV has the potential to interrupt the development of single-ventricle heart disease by restoring proper flow through the heart. Elsevier 2020-07-29 /pmc/articles/PMC7452327/ /pubmed/32875171 http://dx.doi.org/10.1016/j.jacbts.2020.06.009 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Zakko, Jason
Blum, Kevin M.
Drews, Joseph D.
Wu, Yen-Lin
Hatoum, Hoda
Russell, Madeleine
Gooden, Shelley
Heitkemper, Megan
Conroy, Olivia
Kelly, John
Carey, Stacey
Sacks, Michael
Texter, Karen
Ragsdale, Ellie
Strainic, James
Bocks, Martin
Wang, Yadong
Dasi, Lakshmi Prasad
Armstrong, Aimee K.
Breuer, Christopher
Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model
title Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model
title_full Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model
title_fullStr Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model
title_full_unstemmed Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model
title_short Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model
title_sort development of tissue engineered heart valves for percutaneous transcatheter delivery in a fetal ovine model
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452327/
https://www.ncbi.nlm.nih.gov/pubmed/32875171
http://dx.doi.org/10.1016/j.jacbts.2020.06.009
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