Dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model

The transcriptomic dataset (whole genome microarray Affymetrix Human U133 plus 2.0 and Affymetrix Mouse Genome 430 2.0) presented in this paper describes the differential gene expression profile of a human in vitro model of drug-induced cholestasis and a well-known mouse in vivo model of cholestasis...

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Autores principales: Gijbels, Eva, Devisscher, Lindsey, Vinken, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Biochemistry, Genetics and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452704/
https://www.ncbi.nlm.nih.gov/pubmed/32904329
http://dx.doi.org/10.1016/j.dib.2020.106156
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author Gijbels, Eva
Devisscher, Lindsey
Vinken, Mathieu
author_facet Gijbels, Eva
Devisscher, Lindsey
Vinken, Mathieu
author_sort Gijbels, Eva
collection PubMed
description The transcriptomic dataset (whole genome microarray Affymetrix Human U133 plus 2.0 and Affymetrix Mouse Genome 430 2.0) presented in this paper describes the differential gene expression profile of a human in vitro model of drug-induced cholestasis and a well-known mouse in vivo model of cholestasis. The in vitro model consists of human hepatoma HepaRG cells in monolayer configuration exposed to 3 different cholestatic drugs with or without bile acids. For in vivo modelling of cholestasis, mice were subjected to bile duct ligation surgery. Consecutive normalization, summarization and background adjustments have been made by means of Robust Multichip Average Express software.
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spelling pubmed-74527042020-09-03 Dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model Gijbels, Eva Devisscher, Lindsey Vinken, Mathieu Data Brief Biochemistry, Genetics and Molecular Biology The transcriptomic dataset (whole genome microarray Affymetrix Human U133 plus 2.0 and Affymetrix Mouse Genome 430 2.0) presented in this paper describes the differential gene expression profile of a human in vitro model of drug-induced cholestasis and a well-known mouse in vivo model of cholestasis. The in vitro model consists of human hepatoma HepaRG cells in monolayer configuration exposed to 3 different cholestatic drugs with or without bile acids. For in vivo modelling of cholestasis, mice were subjected to bile duct ligation surgery. Consecutive normalization, summarization and background adjustments have been made by means of Robust Multichip Average Express software. Elsevier 2020-08-07 /pmc/articles/PMC7452704/ /pubmed/32904329 http://dx.doi.org/10.1016/j.dib.2020.106156 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Biochemistry, Genetics and Molecular Biology
Gijbels, Eva
Devisscher, Lindsey
Vinken, Mathieu
Dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model
title Dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model
title_full Dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model
title_fullStr Dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model
title_full_unstemmed Dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model
title_short Dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model
title_sort dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model
topic Biochemistry, Genetics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452704/
https://www.ncbi.nlm.nih.gov/pubmed/32904329
http://dx.doi.org/10.1016/j.dib.2020.106156
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