From sequence analysis of DPP-4 to molecular docking based searching of its inhibitors

Literature data suggests that Dipeptidyl peptidase-4 (DPP-4) is a potential target for type 2 Diabetes Mellitus. Therefore, it is of interest to identify new DPP-4 inhibitors using molecular docking analysis. We document compounds such as STOCK1N-98884, STOCK1N-98881, and STOCK1N-98866 with optimal...

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Detalles Bibliográficos
Autores principales: Alsamghan, Awad Saeed, Alwabli, Afaf S, Abadi, Mohammed, Alsaleem, Safar A, Anbari, Dalia Mohammed, Alomari, Amani Saleh, Alzahrani, Othman, Alam, Qamre, Tarique, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452749/
https://www.ncbi.nlm.nih.gov/pubmed/32884207
http://dx.doi.org/10.6026/97320630016444
Descripción
Sumario:Literature data suggests that Dipeptidyl peptidase-4 (DPP-4) is a potential target for type 2 Diabetes Mellitus. Therefore, it is of interest to identify new DPP-4 inhibitors using molecular docking analysis. We document compounds such as STOCK1N-98884, STOCK1N-98881, and STOCK1N-98866 with optimal binding features with DPP-4 from the ligand database at https://www.ibscreen.com/ for further consideration.

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