Cargando…

ENaC in Salt-Sensitive Hypertension: Kidney and Beyond

PURPOSE OF REVIEW: The main goal of this article is to discuss the role of the epithelial sodium channel (ENaC) in extracellular fluid and blood pressure regulation. RECENT FINDINGS: Besides its role in sodium handling in the kidney, recent studies have found that ENaC expressed in other cells inclu...

Descripción completa

Detalles Bibliográficos
Autores principales: Pitzer, Ashley L., Van Beusecum, Justin P., Kleyman, Thomas R., Kirabo, Annet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452925/
https://www.ncbi.nlm.nih.gov/pubmed/32852643
http://dx.doi.org/10.1007/s11906-020-01067-9
_version_ 1783575258456915968
author Pitzer, Ashley L.
Van Beusecum, Justin P.
Kleyman, Thomas R.
Kirabo, Annet
author_facet Pitzer, Ashley L.
Van Beusecum, Justin P.
Kleyman, Thomas R.
Kirabo, Annet
author_sort Pitzer, Ashley L.
collection PubMed
description PURPOSE OF REVIEW: The main goal of this article is to discuss the role of the epithelial sodium channel (ENaC) in extracellular fluid and blood pressure regulation. RECENT FINDINGS: Besides its role in sodium handling in the kidney, recent studies have found that ENaC expressed in other cells including immune cells can influence blood pressure via extra-renal mechanisms. Dendritic cells (DCs) are activated and contribute to salt-sensitive hypertension in an ENaC-dependent manner. We discuss recent studies on how ENaC is regulated in both the kidney and other sites including the vascular smooth muscles, endothelial cells, and immune cells. We also discuss how this extra-renal ENaC can play a role in salt-sensitive hypertension and its promise as a novel therapeutic target. SUMMARY: The role of ENaC in blood pressure regulation in the kidney has been well studied. Recent human gene sequencing efforts have identified thousands of variants among the genes encoding ENaC, and research efforts to determine if these variants and their expression in extra-renal tissue play a role in hypertension will advance our understanding of the pathogenesis of ENaC-mediated cardiovascular disease and lead to novel therapeutic targets.
format Online
Article
Text
id pubmed-7452925
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-74529252020-09-02 ENaC in Salt-Sensitive Hypertension: Kidney and Beyond Pitzer, Ashley L. Van Beusecum, Justin P. Kleyman, Thomas R. Kirabo, Annet Curr Hypertens Rep Inflammation and Cardiovascular Diseases (A Kirabo, Section Editor) PURPOSE OF REVIEW: The main goal of this article is to discuss the role of the epithelial sodium channel (ENaC) in extracellular fluid and blood pressure regulation. RECENT FINDINGS: Besides its role in sodium handling in the kidney, recent studies have found that ENaC expressed in other cells including immune cells can influence blood pressure via extra-renal mechanisms. Dendritic cells (DCs) are activated and contribute to salt-sensitive hypertension in an ENaC-dependent manner. We discuss recent studies on how ENaC is regulated in both the kidney and other sites including the vascular smooth muscles, endothelial cells, and immune cells. We also discuss how this extra-renal ENaC can play a role in salt-sensitive hypertension and its promise as a novel therapeutic target. SUMMARY: The role of ENaC in blood pressure regulation in the kidney has been well studied. Recent human gene sequencing efforts have identified thousands of variants among the genes encoding ENaC, and research efforts to determine if these variants and their expression in extra-renal tissue play a role in hypertension will advance our understanding of the pathogenesis of ENaC-mediated cardiovascular disease and lead to novel therapeutic targets. Springer US 2020-08-27 2020 /pmc/articles/PMC7452925/ /pubmed/32852643 http://dx.doi.org/10.1007/s11906-020-01067-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Inflammation and Cardiovascular Diseases (A Kirabo, Section Editor)
Pitzer, Ashley L.
Van Beusecum, Justin P.
Kleyman, Thomas R.
Kirabo, Annet
ENaC in Salt-Sensitive Hypertension: Kidney and Beyond
title ENaC in Salt-Sensitive Hypertension: Kidney and Beyond
title_full ENaC in Salt-Sensitive Hypertension: Kidney and Beyond
title_fullStr ENaC in Salt-Sensitive Hypertension: Kidney and Beyond
title_full_unstemmed ENaC in Salt-Sensitive Hypertension: Kidney and Beyond
title_short ENaC in Salt-Sensitive Hypertension: Kidney and Beyond
title_sort enac in salt-sensitive hypertension: kidney and beyond
topic Inflammation and Cardiovascular Diseases (A Kirabo, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452925/
https://www.ncbi.nlm.nih.gov/pubmed/32852643
http://dx.doi.org/10.1007/s11906-020-01067-9
work_keys_str_mv AT pitzerashleyl enacinsaltsensitivehypertensionkidneyandbeyond
AT vanbeusecumjustinp enacinsaltsensitivehypertensionkidneyandbeyond
AT kleymanthomasr enacinsaltsensitivehypertensionkidneyandbeyond
AT kiraboannet enacinsaltsensitivehypertensionkidneyandbeyond