The SF3b complex: splicing and beyond

The SF3b complex is an intrinsic component of the functional U2 small nuclear ribonucleoprotein (snRNP). As U2 snRNP enters nuclear pre-mRNA splicing, SF3b plays key roles in recognizing the branch point sequence (BPS) and facilitating spliceosome assembly and activation. Since the discovery of SF3b...

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Autor principal: Sun, Chengfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452928/
https://www.ncbi.nlm.nih.gov/pubmed/32140746
http://dx.doi.org/10.1007/s00018-020-03493-z
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author Sun, Chengfu
author_facet Sun, Chengfu
author_sort Sun, Chengfu
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description The SF3b complex is an intrinsic component of the functional U2 small nuclear ribonucleoprotein (snRNP). As U2 snRNP enters nuclear pre-mRNA splicing, SF3b plays key roles in recognizing the branch point sequence (BPS) and facilitating spliceosome assembly and activation. Since the discovery of SF3b, substantial progress has been made in elucidating its molecular mechanism during splicing. In addition, numerous recent studies indicate that SF3b and its components are engaged in various molecular and cellular events that are beyond the canonical role in splicing. This review summarizes the current knowledge on the SF3b complex and highlights its multiple roles in splicing and beyond.
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spelling pubmed-74529282020-09-02 The SF3b complex: splicing and beyond Sun, Chengfu Cell Mol Life Sci Review The SF3b complex is an intrinsic component of the functional U2 small nuclear ribonucleoprotein (snRNP). As U2 snRNP enters nuclear pre-mRNA splicing, SF3b plays key roles in recognizing the branch point sequence (BPS) and facilitating spliceosome assembly and activation. Since the discovery of SF3b, substantial progress has been made in elucidating its molecular mechanism during splicing. In addition, numerous recent studies indicate that SF3b and its components are engaged in various molecular and cellular events that are beyond the canonical role in splicing. This review summarizes the current knowledge on the SF3b complex and highlights its multiple roles in splicing and beyond. Springer International Publishing 2020-03-05 2020 /pmc/articles/PMC7452928/ /pubmed/32140746 http://dx.doi.org/10.1007/s00018-020-03493-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Sun, Chengfu
The SF3b complex: splicing and beyond
title The SF3b complex: splicing and beyond
title_full The SF3b complex: splicing and beyond
title_fullStr The SF3b complex: splicing and beyond
title_full_unstemmed The SF3b complex: splicing and beyond
title_short The SF3b complex: splicing and beyond
title_sort sf3b complex: splicing and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452928/
https://www.ncbi.nlm.nih.gov/pubmed/32140746
http://dx.doi.org/10.1007/s00018-020-03493-z
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