Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition

BACKGROUND: Patients diagnosed with primary central nervous system lymphoma (PCNSL) often face dismal outcomes due to the limited availability of therapeutic options. PCNSL cells frequently have deregulated B-cell receptor (BCR) signaling, but clinical responses to its inhibition using ibrutinib hav...

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Detalles Bibliográficos
Autores principales: Jiménez, Isabel, Carabia, Júlia, Bobillo, Sabela, Palacio, Carles, Abrisqueta, Pau, Pagès, Carlota, Nieto, Juan C., Castellví, Josep, Martínez-Ricarte, Francisco, Escoda, Lourdes, Perla, Cristóbal, Céspedes Torrez, Dennis H., Boix, Joan, Purroy, Noelia, Puigdefàbregas, Lluís, Seoane, Joan, Bosch, Francesc, Crespo, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Laboratory Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452938/
https://www.ncbi.nlm.nih.gov/pubmed/32691208
http://dx.doi.org/10.1007/s11060-020-03580-y

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