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Recurrence of macular corneal dystrophy on the graft 50 years after penetrating keratoplasty
Purpose: To report the recurrence of a macular corneal stromal dystrophy 50 years after penetrating keratoplasty (PKP). Methods: Observational case report Case description: A 76-year-old male patient presented with visual impairment in the right eye (OD) 50 years after PKP in 1962 (44 years after PK...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
German Medical Science GMS Publishing House
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452946/ https://www.ncbi.nlm.nih.gov/pubmed/32884888 http://dx.doi.org/10.3205/oc000161 |
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author | Bischoff-Jung, Mona Flockerzi, Elias Hasenfus, Andrea Viestenz, Arne Matoula, Pinio Schlötzer-Schrehardt, Ursula Seitz, Berthold |
author_facet | Bischoff-Jung, Mona Flockerzi, Elias Hasenfus, Andrea Viestenz, Arne Matoula, Pinio Schlötzer-Schrehardt, Ursula Seitz, Berthold |
author_sort | Bischoff-Jung, Mona |
collection | PubMed |
description | Purpose: To report the recurrence of a macular corneal stromal dystrophy 50 years after penetrating keratoplasty (PKP). Methods: Observational case report Case description: A 76-year-old male patient presented with visual impairment in the right eye (OD) 50 years after PKP in 1962 (44 years after PKP also in the left eye (OS) in 1968) following explosion injury. His visual acuity had already been impaired before the trauma because of bilateral corneal opacities. The central corneal thickness of the graft measured 584 µm (OD) and 544 µm (OS), whilst the peripheral host thickness (8 mm zone), however, was 1233 µm (OD, cranial) and 1131 µm (OS, nasal). The original graft diameter measured 6 mm in both eyes and the recipient cornea was cloudy and gray. The endothelial cell count was measured centrally (OD 1162 c/mm(2), OS 1320 c/mm(2)). The visual acuity was 20/100 (OD) and 20/40 (OS). After excimerlaser-assisted repeated PKP (8.0/8.1 mm, OD), the histological analysis of the former graft revealed deposits of acid mucopolysaccharides (AMP) subepithelially, within the interface, in the donor stroma, and in the endothelium, which proved the peripheral recurrence of a macular corneal stromal dystrophy on the graft. Conclusion: Recurrence of macular corneal stromal dystrophy is seldom, but it may occur many decades after PKP. In this patient, the host’s stroma was twice as thick as that of the graft. This may be caused by the active production of acid mucopolysaccharides in the host endothelium with secondary endothelial decompensation. Thus, PKP remains the gold standard in the cure of macular corneal dystrophy for long-term visual rehabilitation. |
format | Online Article Text |
id | pubmed-7452946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | German Medical Science GMS Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-74529462020-09-02 Recurrence of macular corneal dystrophy on the graft 50 years after penetrating keratoplasty Bischoff-Jung, Mona Flockerzi, Elias Hasenfus, Andrea Viestenz, Arne Matoula, Pinio Schlötzer-Schrehardt, Ursula Seitz, Berthold GMS Ophthalmol Cases Article Purpose: To report the recurrence of a macular corneal stromal dystrophy 50 years after penetrating keratoplasty (PKP). Methods: Observational case report Case description: A 76-year-old male patient presented with visual impairment in the right eye (OD) 50 years after PKP in 1962 (44 years after PKP also in the left eye (OS) in 1968) following explosion injury. His visual acuity had already been impaired before the trauma because of bilateral corneal opacities. The central corneal thickness of the graft measured 584 µm (OD) and 544 µm (OS), whilst the peripheral host thickness (8 mm zone), however, was 1233 µm (OD, cranial) and 1131 µm (OS, nasal). The original graft diameter measured 6 mm in both eyes and the recipient cornea was cloudy and gray. The endothelial cell count was measured centrally (OD 1162 c/mm(2), OS 1320 c/mm(2)). The visual acuity was 20/100 (OD) and 20/40 (OS). After excimerlaser-assisted repeated PKP (8.0/8.1 mm, OD), the histological analysis of the former graft revealed deposits of acid mucopolysaccharides (AMP) subepithelially, within the interface, in the donor stroma, and in the endothelium, which proved the peripheral recurrence of a macular corneal stromal dystrophy on the graft. Conclusion: Recurrence of macular corneal stromal dystrophy is seldom, but it may occur many decades after PKP. In this patient, the host’s stroma was twice as thick as that of the graft. This may be caused by the active production of acid mucopolysaccharides in the host endothelium with secondary endothelial decompensation. Thus, PKP remains the gold standard in the cure of macular corneal dystrophy for long-term visual rehabilitation. German Medical Science GMS Publishing House 2020-08-06 /pmc/articles/PMC7452946/ /pubmed/32884888 http://dx.doi.org/10.3205/oc000161 Text en Copyright © 2020 Bischoff-Jung et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bischoff-Jung, Mona Flockerzi, Elias Hasenfus, Andrea Viestenz, Arne Matoula, Pinio Schlötzer-Schrehardt, Ursula Seitz, Berthold Recurrence of macular corneal dystrophy on the graft 50 years after penetrating keratoplasty |
title | Recurrence of macular corneal dystrophy on the graft 50 years after penetrating keratoplasty |
title_full | Recurrence of macular corneal dystrophy on the graft 50 years after penetrating keratoplasty |
title_fullStr | Recurrence of macular corneal dystrophy on the graft 50 years after penetrating keratoplasty |
title_full_unstemmed | Recurrence of macular corneal dystrophy on the graft 50 years after penetrating keratoplasty |
title_short | Recurrence of macular corneal dystrophy on the graft 50 years after penetrating keratoplasty |
title_sort | recurrence of macular corneal dystrophy on the graft 50 years after penetrating keratoplasty |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452946/ https://www.ncbi.nlm.nih.gov/pubmed/32884888 http://dx.doi.org/10.3205/oc000161 |
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