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Cellular metabolism and homeostasis in pluripotency regulation
Pluripotent stem cells (PSCs) can immortally self-renew in culture with a high proliferation rate, and they possess unique metabolic characteristics that facilitate pluripotency regulation. Here, we review recent progress in understanding the mechanisms that link cellular metabolism and homeostasis...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Higher Education Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452966/ https://www.ncbi.nlm.nih.gov/pubmed/32643102 http://dx.doi.org/10.1007/s13238-020-00755-1 |
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author | Liu, Kun Cao, Jiani Shi, Xingxing Wang, Liang Zhao, Tongbiao |
author_facet | Liu, Kun Cao, Jiani Shi, Xingxing Wang, Liang Zhao, Tongbiao |
author_sort | Liu, Kun |
collection | PubMed |
description | Pluripotent stem cells (PSCs) can immortally self-renew in culture with a high proliferation rate, and they possess unique metabolic characteristics that facilitate pluripotency regulation. Here, we review recent progress in understanding the mechanisms that link cellular metabolism and homeostasis to pluripotency regulation, with particular emphasis on pathways involving amino acid metabolism, lipid metabolism, the ubiquitin-proteasome system and autophagy. Metabolism of amino acids and lipids is tightly coupled to epigenetic modification, organelle remodeling and cell signaling pathways for pluripotency regulation. PSCs harness enhanced proteasome and autophagy activity to meet the material and energy requirements for cellular homeostasis. These regulatory events reflect a fine balance between the intrinsic cellular requirements and the extrinsic environment. A more complete understanding of this balance will pave new ways to manipulate PSC fate. |
format | Online Article Text |
id | pubmed-7452966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Higher Education Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74529662020-09-03 Cellular metabolism and homeostasis in pluripotency regulation Liu, Kun Cao, Jiani Shi, Xingxing Wang, Liang Zhao, Tongbiao Protein Cell Review Pluripotent stem cells (PSCs) can immortally self-renew in culture with a high proliferation rate, and they possess unique metabolic characteristics that facilitate pluripotency regulation. Here, we review recent progress in understanding the mechanisms that link cellular metabolism and homeostasis to pluripotency regulation, with particular emphasis on pathways involving amino acid metabolism, lipid metabolism, the ubiquitin-proteasome system and autophagy. Metabolism of amino acids and lipids is tightly coupled to epigenetic modification, organelle remodeling and cell signaling pathways for pluripotency regulation. PSCs harness enhanced proteasome and autophagy activity to meet the material and energy requirements for cellular homeostasis. These regulatory events reflect a fine balance between the intrinsic cellular requirements and the extrinsic environment. A more complete understanding of this balance will pave new ways to manipulate PSC fate. Higher Education Press 2020-07-08 2020-09 /pmc/articles/PMC7452966/ /pubmed/32643102 http://dx.doi.org/10.1007/s13238-020-00755-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Liu, Kun Cao, Jiani Shi, Xingxing Wang, Liang Zhao, Tongbiao Cellular metabolism and homeostasis in pluripotency regulation |
title | Cellular metabolism and homeostasis in pluripotency regulation |
title_full | Cellular metabolism and homeostasis in pluripotency regulation |
title_fullStr | Cellular metabolism and homeostasis in pluripotency regulation |
title_full_unstemmed | Cellular metabolism and homeostasis in pluripotency regulation |
title_short | Cellular metabolism and homeostasis in pluripotency regulation |
title_sort | cellular metabolism and homeostasis in pluripotency regulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452966/ https://www.ncbi.nlm.nih.gov/pubmed/32643102 http://dx.doi.org/10.1007/s13238-020-00755-1 |
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