Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Older organs represent an untapped potential to close the gap between demand and supply in organ transplantation but are associated with age-specific responses to injury and increased immunogenicity, thereby aggravating transplant outcomes. Here we show that cell-free mitochondrial DNA (cf-mt-DNA) r...

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Detalles Bibliográficos
Autores principales: Iske, Jasper, Seyda, Midas, Heinbokel, Timm, Maenosono, Ryoichi, Minami, Koichiro, Nian, Yeqi, Quante, Markus, Falk, Christine S., Azuma, Haruhito, Martin, Friederike, Passos, João F., Niemann, Claus U., Tchkonia, Tamara, Kirkland, James L., Elkhal, Abdallah, Tullius, Stefan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453018/
https://www.ncbi.nlm.nih.gov/pubmed/32855397
http://dx.doi.org/10.1038/s41467-020-18039-x

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