Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

The main protease, M(pro) (or 3CL(pro)) in SARS-CoV-2 is a viable drug target because of its essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal coronavirus infection in cats, was successfully treated previously with a prodrug GC376, a dipeptide-based prot...

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Detalles Bibliográficos
Autores principales: Vuong, Wayne, Khan, Muhammad Bashir, Fischer, Conrad, Arutyunova, Elena, Lamer, Tess, Shields, Justin, Saffran, Holly A., McKay, Ryan T., van Belkum, Marco J., Joyce, Michael A., Young, Howard S., Tyrrell, D. Lorne, Vederas, John C., Lemieux, M. Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453019/
https://www.ncbi.nlm.nih.gov/pubmed/32855413
http://dx.doi.org/10.1038/s41467-020-18096-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453019/
https://www.ncbi.nlm.nih.gov/pubmed/32855413
http://dx.doi.org/10.1038/s41467-020-18096-2

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