Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

Pulmonary disease increases the risk of developing abdominal aortic aneurysms (AAA). However, the mechanism underlying the pathological dialogue between the lungs and aorta is undefined. Here, we find that inflicting acute lung injury (ALI) to mice doubles their incidence of AAA and accelerates macr...

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Detalles Bibliográficos
Autores principales: Boytard, Ludovic, Hadi, Tarik, Silvestro, Michele, Qu, Hengdong, Kumpfbeck, Andrew, Sleiman, Rayan, Fils, Kissinger Hyppolite, Alebrahim, Dornazsadat, Boccalatte, Francesco, Kugler, Matthias, Corsica, Annanina, Gelb, Bruce E., Jacobowitz, Glenn, Miller, George, Bellini, Chiara, Oakes, Jessica, Silvestre, Jean-Sébastien, Zangi, Lior, Ramkhelawon, Bhama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453029/
https://www.ncbi.nlm.nih.gov/pubmed/32855420
http://dx.doi.org/10.1038/s41467-020-18088-2

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