Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases

Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding the evolution of the disease could help inform patient management. Through whole-genome sequencing of 13 melanoma metastases sampled at autopsy from a treatment naïve patient and by leveraging the analytica...

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Detalles Bibliográficos
Autores principales: Rabbie, Roy, Ansari-Pour, Naser, Cast, Oliver, Lau, Doreen, Scott, Francis, Welsh, Sarah J., Parkinson, Christine, Khoja, Leila, Moore, Luiza, Tullett, Mark, Wong, Kim, Ferreira, Ingrid, Gómez, Julia M. Martínez, Levesque, Mitchell, Gallagher, Ferdia A., Jiménez-Sánchez, Alejandro, Riva, Laura, Miller, Martin L., Allinson, Kieren, Campbell, Peter J., Corrie, Pippa, Wedge, David C., Adams, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453196/
https://www.ncbi.nlm.nih.gov/pubmed/32855398
http://dx.doi.org/10.1038/s41467-020-18060-0

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