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Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects

To examine the hypothesis that normalization of low circulating leptin levels in patients with anorexia nervosa ameliorates hyperactivity, three seriously ill females with hyperactivity were treated off-label with metreleptin (recombinant human leptin) for up to 14 days. Drive for activity, repetiti...

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Autores principales: Milos, Gabriella, Antel, Jochen, Kaufmann, Lisa-Katrin, Barth, Nikolaus, Koller, Antonia, Tan, Susanne, Wiesing, Urban, Hinney, Anke, Libuda, Lars, Wabitsch, Martin, von Känel, Roland, Hebebrand, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453199/
https://www.ncbi.nlm.nih.gov/pubmed/32855384
http://dx.doi.org/10.1038/s41398-020-00977-1
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author Milos, Gabriella
Antel, Jochen
Kaufmann, Lisa-Katrin
Barth, Nikolaus
Koller, Antonia
Tan, Susanne
Wiesing, Urban
Hinney, Anke
Libuda, Lars
Wabitsch, Martin
von Känel, Roland
Hebebrand, Johannes
author_facet Milos, Gabriella
Antel, Jochen
Kaufmann, Lisa-Katrin
Barth, Nikolaus
Koller, Antonia
Tan, Susanne
Wiesing, Urban
Hinney, Anke
Libuda, Lars
Wabitsch, Martin
von Känel, Roland
Hebebrand, Johannes
author_sort Milos, Gabriella
collection PubMed
description To examine the hypothesis that normalization of low circulating leptin levels in patients with anorexia nervosa ameliorates hyperactivity, three seriously ill females with hyperactivity were treated off-label with metreleptin (recombinant human leptin) for up to 14 days. Drive for activity, repetitive thoughts of food, inner restlessness, and weight phobia decreased in two patients. Surprisingly, depression improved rapidly in all patients. No serious adverse events occurred. Due to obvious limitations of uncontrolled case series, placebo-controlled clinical trials are mandatory to confirm the observed rapid onset of beneficial effects. Our findings suggest an important role of hypoleptinemia in the mental and behavioral phenotype of anorexia nervosa.
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spelling pubmed-74531992020-09-03 Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects Milos, Gabriella Antel, Jochen Kaufmann, Lisa-Katrin Barth, Nikolaus Koller, Antonia Tan, Susanne Wiesing, Urban Hinney, Anke Libuda, Lars Wabitsch, Martin von Känel, Roland Hebebrand, Johannes Transl Psychiatry Article To examine the hypothesis that normalization of low circulating leptin levels in patients with anorexia nervosa ameliorates hyperactivity, three seriously ill females with hyperactivity were treated off-label with metreleptin (recombinant human leptin) for up to 14 days. Drive for activity, repetitive thoughts of food, inner restlessness, and weight phobia decreased in two patients. Surprisingly, depression improved rapidly in all patients. No serious adverse events occurred. Due to obvious limitations of uncontrolled case series, placebo-controlled clinical trials are mandatory to confirm the observed rapid onset of beneficial effects. Our findings suggest an important role of hypoleptinemia in the mental and behavioral phenotype of anorexia nervosa. Nature Publishing Group UK 2020-08-27 /pmc/articles/PMC7453199/ /pubmed/32855384 http://dx.doi.org/10.1038/s41398-020-00977-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Milos, Gabriella
Antel, Jochen
Kaufmann, Lisa-Katrin
Barth, Nikolaus
Koller, Antonia
Tan, Susanne
Wiesing, Urban
Hinney, Anke
Libuda, Lars
Wabitsch, Martin
von Känel, Roland
Hebebrand, Johannes
Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
title Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
title_full Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
title_fullStr Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
title_full_unstemmed Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
title_short Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
title_sort short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453199/
https://www.ncbi.nlm.nih.gov/pubmed/32855384
http://dx.doi.org/10.1038/s41398-020-00977-1
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