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Replicating and projecting the path of COVID-19 with a model-implied reproduction number

We demonstrate a methodology for replicating and projecting the path of COVID-19 using a simple epidemiology model. We fit the model to daily data on the number of infected cases in China, Italy, the United States, and Brazil. These four countries can be viewed as representing different stages, from...

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Autores principales: Buckman, Shelby R., Glick, Reuven, Lansing, Kevin J., Petrosky-Nadeau, Nicolas, Seitelman, Lily M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453227/
https://www.ncbi.nlm.nih.gov/pubmed/32875176
http://dx.doi.org/10.1016/j.idm.2020.08.007
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author Buckman, Shelby R.
Glick, Reuven
Lansing, Kevin J.
Petrosky-Nadeau, Nicolas
Seitelman, Lily M.
author_facet Buckman, Shelby R.
Glick, Reuven
Lansing, Kevin J.
Petrosky-Nadeau, Nicolas
Seitelman, Lily M.
author_sort Buckman, Shelby R.
collection PubMed
description We demonstrate a methodology for replicating and projecting the path of COVID-19 using a simple epidemiology model. We fit the model to daily data on the number of infected cases in China, Italy, the United States, and Brazil. These four countries can be viewed as representing different stages, from later to earlier, of a COVID-19 epidemic cycle. We solve for a model-implied effective reproduction number [Formula: see text] each day so that the model closely replicates the daily number of currently infected cases in each country. For out-of-sample projections, we fit a behavioral function to the in-sample data that allows for the endogenous response of [Formula: see text] to movements in the lagged number of infected cases. We show that declines in measures of population mobility tend to precede declines in the model-implied reproduction numbers for each country. This pattern suggests that mandatory and voluntary stay-at-home behavior and social distancing during the early stages of the epidemic worked to reduce the effective reproduction number and mitigate the spread of COVID-19.
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spelling pubmed-74532272020-08-28 Replicating and projecting the path of COVID-19 with a model-implied reproduction number Buckman, Shelby R. Glick, Reuven Lansing, Kevin J. Petrosky-Nadeau, Nicolas Seitelman, Lily M. Infect Dis Model Special issue on Modelling and Forecasting the 2019 Novel Coronavirus (2019-nCoV) Transmission; Edited by Prof. Carlos Castillo-Chavez, Prof. Gerardo Chowell-Puente, Prof. Ping Yan, Prof. Jianhong Wu We demonstrate a methodology for replicating and projecting the path of COVID-19 using a simple epidemiology model. We fit the model to daily data on the number of infected cases in China, Italy, the United States, and Brazil. These four countries can be viewed as representing different stages, from later to earlier, of a COVID-19 epidemic cycle. We solve for a model-implied effective reproduction number [Formula: see text] each day so that the model closely replicates the daily number of currently infected cases in each country. For out-of-sample projections, we fit a behavioral function to the in-sample data that allows for the endogenous response of [Formula: see text] to movements in the lagged number of infected cases. We show that declines in measures of population mobility tend to precede declines in the model-implied reproduction numbers for each country. This pattern suggests that mandatory and voluntary stay-at-home behavior and social distancing during the early stages of the epidemic worked to reduce the effective reproduction number and mitigate the spread of COVID-19. KeAi Publishing 2020-08-28 /pmc/articles/PMC7453227/ /pubmed/32875176 http://dx.doi.org/10.1016/j.idm.2020.08.007 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Special issue on Modelling and Forecasting the 2019 Novel Coronavirus (2019-nCoV) Transmission; Edited by Prof. Carlos Castillo-Chavez, Prof. Gerardo Chowell-Puente, Prof. Ping Yan, Prof. Jianhong Wu
Buckman, Shelby R.
Glick, Reuven
Lansing, Kevin J.
Petrosky-Nadeau, Nicolas
Seitelman, Lily M.
Replicating and projecting the path of COVID-19 with a model-implied reproduction number
title Replicating and projecting the path of COVID-19 with a model-implied reproduction number
title_full Replicating and projecting the path of COVID-19 with a model-implied reproduction number
title_fullStr Replicating and projecting the path of COVID-19 with a model-implied reproduction number
title_full_unstemmed Replicating and projecting the path of COVID-19 with a model-implied reproduction number
title_short Replicating and projecting the path of COVID-19 with a model-implied reproduction number
title_sort replicating and projecting the path of covid-19 with a model-implied reproduction number
topic Special issue on Modelling and Forecasting the 2019 Novel Coronavirus (2019-nCoV) Transmission; Edited by Prof. Carlos Castillo-Chavez, Prof. Gerardo Chowell-Puente, Prof. Ping Yan, Prof. Jianhong Wu
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453227/
https://www.ncbi.nlm.nih.gov/pubmed/32875176
http://dx.doi.org/10.1016/j.idm.2020.08.007
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