The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune...

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Autores principales: Zhu, Xueyi, Cui, Jie, Yi, La, Qin, Jingjing, Tulake, Wuniqiemu, Teng, Fangzhou, Tang, Weifeng, Wei, Ying, Dong, Jingcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453253/
https://www.ncbi.nlm.nih.gov/pubmed/32922208
http://dx.doi.org/10.1155/2020/7835284
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author Zhu, Xueyi
Cui, Jie
Yi, La
Qin, Jingjing
Tulake, Wuniqiemu
Teng, Fangzhou
Tang, Weifeng
Wei, Ying
Dong, Jingcheng
author_facet Zhu, Xueyi
Cui, Jie
Yi, La
Qin, Jingjing
Tulake, Wuniqiemu
Teng, Fangzhou
Tang, Weifeng
Wei, Ying
Dong, Jingcheng
author_sort Zhu, Xueyi
collection PubMed
description Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune cell activation or repression in the immune response. Consequently, the imbalanced immune microenvironment is the major cause of the exacerbation of asthma. Here, we discuss the role of T cells, macrophages, and their interactions in asthma pathogenesis.
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spelling pubmed-74532532020-09-11 The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk Zhu, Xueyi Cui, Jie Yi, La Qin, Jingjing Tulake, Wuniqiemu Teng, Fangzhou Tang, Weifeng Wei, Ying Dong, Jingcheng Mediators Inflamm Research Article Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune cell activation or repression in the immune response. Consequently, the imbalanced immune microenvironment is the major cause of the exacerbation of asthma. Here, we discuss the role of T cells, macrophages, and their interactions in asthma pathogenesis. Hindawi 2020-08-19 /pmc/articles/PMC7453253/ /pubmed/32922208 http://dx.doi.org/10.1155/2020/7835284 Text en Copyright © 2020 Xueyi Zhu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhu, Xueyi
Cui, Jie
Yi, La
Qin, Jingjing
Tulake, Wuniqiemu
Teng, Fangzhou
Tang, Weifeng
Wei, Ying
Dong, Jingcheng
The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk
title The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk
title_full The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk
title_fullStr The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk
title_full_unstemmed The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk
title_short The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk
title_sort role of t cells and macrophages in asthma pathogenesis: a new perspective on mutual crosstalk
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453253/
https://www.ncbi.nlm.nih.gov/pubmed/32922208
http://dx.doi.org/10.1155/2020/7835284
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