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Investigating the correlation between DNA methylation and immune-associated genes of lung adenocarcinoma based on a competing endogenous RNA network
In recent years, there have been major breakthroughs in immunotherapies for the treatment of cancer. However, different patients have different responses to immunotherapy. Numerous studies have shown that the accumulation of epigenetic abnormalities, such as DNA methylation, serve an important role...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453503/ https://www.ncbi.nlm.nih.gov/pubmed/32945447 http://dx.doi.org/10.3892/mmr.2020.11445 |
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author | Chang, Chun Kong, Wei Mou, Xiaoyang Wang, Shuaiqun |
author_facet | Chang, Chun Kong, Wei Mou, Xiaoyang Wang, Shuaiqun |
author_sort | Chang, Chun |
collection | PubMed |
description | In recent years, there have been major breakthroughs in immunotherapies for the treatment of cancer. However, different patients have different responses to immunotherapy. Numerous studies have shown that the accumulation of epigenetic abnormalities, such as DNA methylation, serve an important role in the immune response of lung adenocarcinoma (LUAD). To investigate the effects of DNA methylation on tumor immunity with survival and prognosis, relevant studies can be performed based on the regulatory mechanisms of RNA molecules. For example, long non-coding RNAs (lncRNAs), which regulate gene expression through epigenetic levels. By constructing an immune-associated competitive endogenous RNA (ceRNA) network, the present study identified the regulatory associations among 3 key immune-associations mRNAs, 2 microRNAs (miRs) and 29 lncRNAs that were closely associated with the prognosis of patients with LUAD. The molecular biology analysis indicated that hypomethylation of the 1101320–1104290 regions of chromosome 1 resulted in the low expression levels of LINC00337 and that LINC00337 may affect the expression levels of CHEK1 by competitively binding with human (has)-miR-373 and hsa-miR-195. Therefore, abnormal DNA methylation in lncRNA-associated regions caused their abnormal expression levels, which further affected the interactions between RNA molecules. The interactions between these RNA molecules may have regulatory effects on tumor immunity and the prognosis of patients with LUAD. |
format | Online Article Text |
id | pubmed-7453503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-74535032020-08-31 Investigating the correlation between DNA methylation and immune-associated genes of lung adenocarcinoma based on a competing endogenous RNA network Chang, Chun Kong, Wei Mou, Xiaoyang Wang, Shuaiqun Mol Med Rep Articles In recent years, there have been major breakthroughs in immunotherapies for the treatment of cancer. However, different patients have different responses to immunotherapy. Numerous studies have shown that the accumulation of epigenetic abnormalities, such as DNA methylation, serve an important role in the immune response of lung adenocarcinoma (LUAD). To investigate the effects of DNA methylation on tumor immunity with survival and prognosis, relevant studies can be performed based on the regulatory mechanisms of RNA molecules. For example, long non-coding RNAs (lncRNAs), which regulate gene expression through epigenetic levels. By constructing an immune-associated competitive endogenous RNA (ceRNA) network, the present study identified the regulatory associations among 3 key immune-associations mRNAs, 2 microRNAs (miRs) and 29 lncRNAs that were closely associated with the prognosis of patients with LUAD. The molecular biology analysis indicated that hypomethylation of the 1101320–1104290 regions of chromosome 1 resulted in the low expression levels of LINC00337 and that LINC00337 may affect the expression levels of CHEK1 by competitively binding with human (has)-miR-373 and hsa-miR-195. Therefore, abnormal DNA methylation in lncRNA-associated regions caused their abnormal expression levels, which further affected the interactions between RNA molecules. The interactions between these RNA molecules may have regulatory effects on tumor immunity and the prognosis of patients with LUAD. D.A. Spandidos 2020-10 2020-08-19 /pmc/articles/PMC7453503/ /pubmed/32945447 http://dx.doi.org/10.3892/mmr.2020.11445 Text en Copyright: © Chang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Chang, Chun Kong, Wei Mou, Xiaoyang Wang, Shuaiqun Investigating the correlation between DNA methylation and immune-associated genes of lung adenocarcinoma based on a competing endogenous RNA network |
title | Investigating the correlation between DNA methylation and immune-associated genes of lung adenocarcinoma based on a competing endogenous RNA network |
title_full | Investigating the correlation between DNA methylation and immune-associated genes of lung adenocarcinoma based on a competing endogenous RNA network |
title_fullStr | Investigating the correlation between DNA methylation and immune-associated genes of lung adenocarcinoma based on a competing endogenous RNA network |
title_full_unstemmed | Investigating the correlation between DNA methylation and immune-associated genes of lung adenocarcinoma based on a competing endogenous RNA network |
title_short | Investigating the correlation between DNA methylation and immune-associated genes of lung adenocarcinoma based on a competing endogenous RNA network |
title_sort | investigating the correlation between dna methylation and immune-associated genes of lung adenocarcinoma based on a competing endogenous rna network |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453503/ https://www.ncbi.nlm.nih.gov/pubmed/32945447 http://dx.doi.org/10.3892/mmr.2020.11445 |
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