Effects of simvastatin on iNOS and caspase-3 levels and oxidative stress following smoke inhalation injury

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The overexpression of inducible nitric oxide synthase (iNOS) induces cell apoptosis through various signal transduction pathways and aggravates lung injury. Caspase-3 is an important protein in the apoptotic pathway and its activation can exacerbate apoptosis. Simvastatin, a hydroxymethyl glutaryl-A...

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Detalles Bibliográficos
Autores principales: Yang, Rong-Qiang, Guo, Peng-Fei, Ma, Zhao, Chang, Cheng, Meng, Qing-Nan, Gao, Ya, Khan, Imran, Wang, Xiao-Bo, Cui, Zheng-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453554/
https://www.ncbi.nlm.nih.gov/pubmed/32945441
http://dx.doi.org/10.3892/mmr.2020.11413
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