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Novel oral plasminogen activator inhibitor-1 inhibitor TM5275 attenuates hepatic fibrosis under metabolic syndrome via suppression of activated hepatic stellate cells in rats
An orally bioavailable small molecule inhibitor of plasminogen activator inhibitor-1 (PAI-1) is currently being clinically assessed as a novel antithrombotic agent. Although PAI-1 is known to serve a key role in the pathogenesis of metabolic syndrome (MetS) including nonalcoholic steatohepatitis (NA...
Autores principales: | Noguchi, Ryuichi, Kaji, Kosuke, Namisaki, Tadashi, Moriya, Kei, Kawaratani, Hideto, Kitade, Mitsuteru, Takaya, Hiroaki, Aihara, Yosuke, Douhara, Akitoshi, Asada, Kiyoshi, Nishimura, Norihisa, Miyata, Toshio, Yoshiji, Hitoshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453658/ https://www.ncbi.nlm.nih.gov/pubmed/32945412 http://dx.doi.org/10.3892/mmr.2020.11360 |
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