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Eight-year trends in the relative isolation frequency and antimicrobial susceptibility among bloodstream isolates from Greek hospitals: data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance – WHONET-Greece, 2010 to 2017
BACKGROUND: Antimicrobial resistance (AMR) changes over time and continuous monitoring provides insight on trends to inform both empirical treatment and public health action. AIMS: To survey trends in relative isolation frequency (RIF) and AMR among key bloodstream pathogens using data from the Gree...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453683/ https://www.ncbi.nlm.nih.gov/pubmed/32856583 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.34.1900516 |
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| author | Polemis, Michalis Tryfinopoulou, Kyriaki Giakkoupi, Panagiota Vatopoulos, Alkiviadis Koteli, A Fitas, P Economou, M Konsolakis, C Fountoulis, Κ Perivolioti, E Vagiakou, H Ganteris, G Tsorlini, E Vagdatli, E Karantani, A Tsiplakou, S Papaioannou, V Maropoulos, G Deliolanis, I Lebessi, E Doudoulakakis, A Baka, V Platania, A Chinou, E Martsoukou, M Velentza, K Karabela, S Moraitou, ES Kazila, P Digalaki, K Zarkotou, O Papadogianni, M Zervaki, K Karatzoglou, I Platsouka, E Roussou, Z Markou, F Thomoglou, V Stamatopoulou, G Mournianakis, E Theodorakos, I Skoura, L Protonotariou, E Panopoulou, M Koutsidou, A Petinaki, E Vasdeki, A |
| author_facet | Polemis, Michalis Tryfinopoulou, Kyriaki Giakkoupi, Panagiota Vatopoulos, Alkiviadis Koteli, A Fitas, P Economou, M Konsolakis, C Fountoulis, Κ Perivolioti, E Vagiakou, H Ganteris, G Tsorlini, E Vagdatli, E Karantani, A Tsiplakou, S Papaioannou, V Maropoulos, G Deliolanis, I Lebessi, E Doudoulakakis, A Baka, V Platania, A Chinou, E Martsoukou, M Velentza, K Karabela, S Moraitou, ES Kazila, P Digalaki, K Zarkotou, O Papadogianni, M Zervaki, K Karatzoglou, I Platsouka, E Roussou, Z Markou, F Thomoglou, V Stamatopoulou, G Mournianakis, E Theodorakos, I Skoura, L Protonotariou, E Panopoulou, M Koutsidou, A Petinaki, E Vasdeki, A |
| author_sort | Polemis, Michalis |
| collection | PubMed |
| description | BACKGROUND: Antimicrobial resistance (AMR) changes over time and continuous monitoring provides insight on trends to inform both empirical treatment and public health action. AIMS: To survey trends in relative isolation frequency (RIF) and AMR among key bloodstream pathogens using data from the Greek Electronic System for the Surveillance of AMR (WHONET-Greece). METHODS: This observational study looked into routine susceptibility data of 50,488 blood culture isolates from hospitalised patients in 25 tertiary hospitals, participating in the WHONET-Greece for trends over time between January 2010 and December 2017. Only the first isolate per species from each patient was included. Hospital wards and intensive care units (ICUs) were analysed separately. RESULTS: During the study, the RIF of Acinetobacter baumannii increased in wards, as did the proportion of A. baumannii isolates, which were non-susceptibleto most antibiotics in both wards and ICUs. Coincidently, Klebsiella pneumoniae RIF declined while the respective rates of non-susceptible isolates to carbapenems and gentamicin increased. Pseudomonas aeruginosa RIF remained stable but decreasing proportions of non-susceptible isolates to all studied antibiotics, except imipenem were observed. Escherichia coli RIF increased as did the proportion of isolates non-susceptible to third-generation cephalosporins, carbapenems and fluoroquinolones. Concerning Staphylococcus aureus, a decline in the percentage of meticillin resistant isolates in ICUs was found, while the percentages of Enterococcus faecium isolates with non-susceptibility to vancomycin stayed stable. CONCLUSIONS: Recognising these trends over time is important, since the epidemiology of AMR is complex, involving different ‘bug and drug’ combinations. This should be taken into consideration to control AMR. |
| format | Online Article Text |
| id | pubmed-7453683 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | European Centre for Disease Prevention and Control (ECDC) |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-74536832020-08-31 Eight-year trends in the relative isolation frequency and antimicrobial susceptibility among bloodstream isolates from Greek hospitals: data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance – WHONET-Greece, 2010 to 2017 Polemis, Michalis Tryfinopoulou, Kyriaki Giakkoupi, Panagiota Vatopoulos, Alkiviadis Koteli, A Fitas, P Economou, M Konsolakis, C Fountoulis, Κ Perivolioti, E Vagiakou, H Ganteris, G Tsorlini, E Vagdatli, E Karantani, A Tsiplakou, S Papaioannou, V Maropoulos, G Deliolanis, I Lebessi, E Doudoulakakis, A Baka, V Platania, A Chinou, E Martsoukou, M Velentza, K Karabela, S Moraitou, ES Kazila, P Digalaki, K Zarkotou, O Papadogianni, M Zervaki, K Karatzoglou, I Platsouka, E Roussou, Z Markou, F Thomoglou, V Stamatopoulou, G Mournianakis, E Theodorakos, I Skoura, L Protonotariou, E Panopoulou, M Koutsidou, A Petinaki, E Vasdeki, A Euro Surveill Surveillance BACKGROUND: Antimicrobial resistance (AMR) changes over time and continuous monitoring provides insight on trends to inform both empirical treatment and public health action. AIMS: To survey trends in relative isolation frequency (RIF) and AMR among key bloodstream pathogens using data from the Greek Electronic System for the Surveillance of AMR (WHONET-Greece). METHODS: This observational study looked into routine susceptibility data of 50,488 blood culture isolates from hospitalised patients in 25 tertiary hospitals, participating in the WHONET-Greece for trends over time between January 2010 and December 2017. Only the first isolate per species from each patient was included. Hospital wards and intensive care units (ICUs) were analysed separately. RESULTS: During the study, the RIF of Acinetobacter baumannii increased in wards, as did the proportion of A. baumannii isolates, which were non-susceptibleto most antibiotics in both wards and ICUs. Coincidently, Klebsiella pneumoniae RIF declined while the respective rates of non-susceptible isolates to carbapenems and gentamicin increased. Pseudomonas aeruginosa RIF remained stable but decreasing proportions of non-susceptible isolates to all studied antibiotics, except imipenem were observed. Escherichia coli RIF increased as did the proportion of isolates non-susceptible to third-generation cephalosporins, carbapenems and fluoroquinolones. Concerning Staphylococcus aureus, a decline in the percentage of meticillin resistant isolates in ICUs was found, while the percentages of Enterococcus faecium isolates with non-susceptibility to vancomycin stayed stable. CONCLUSIONS: Recognising these trends over time is important, since the epidemiology of AMR is complex, involving different ‘bug and drug’ combinations. This should be taken into consideration to control AMR. European Centre for Disease Prevention and Control (ECDC) 2020-08-27 /pmc/articles/PMC7453683/ /pubmed/32856583 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.34.1900516 Text en This article is copyright of the authors or their affiliated institutions, 2020. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
| spellingShingle | Surveillance Polemis, Michalis Tryfinopoulou, Kyriaki Giakkoupi, Panagiota Vatopoulos, Alkiviadis Koteli, A Fitas, P Economou, M Konsolakis, C Fountoulis, Κ Perivolioti, E Vagiakou, H Ganteris, G Tsorlini, E Vagdatli, E Karantani, A Tsiplakou, S Papaioannou, V Maropoulos, G Deliolanis, I Lebessi, E Doudoulakakis, A Baka, V Platania, A Chinou, E Martsoukou, M Velentza, K Karabela, S Moraitou, ES Kazila, P Digalaki, K Zarkotou, O Papadogianni, M Zervaki, K Karatzoglou, I Platsouka, E Roussou, Z Markou, F Thomoglou, V Stamatopoulou, G Mournianakis, E Theodorakos, I Skoura, L Protonotariou, E Panopoulou, M Koutsidou, A Petinaki, E Vasdeki, A Eight-year trends in the relative isolation frequency and antimicrobial susceptibility among bloodstream isolates from Greek hospitals: data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance – WHONET-Greece, 2010 to 2017 |
| title | Eight-year trends in the relative isolation frequency and antimicrobial susceptibility among bloodstream isolates from Greek hospitals: data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance – WHONET-Greece, 2010 to 2017 |
| title_full | Eight-year trends in the relative isolation frequency and antimicrobial susceptibility among bloodstream isolates from Greek hospitals: data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance – WHONET-Greece, 2010 to 2017 |
| title_fullStr | Eight-year trends in the relative isolation frequency and antimicrobial susceptibility among bloodstream isolates from Greek hospitals: data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance – WHONET-Greece, 2010 to 2017 |
| title_full_unstemmed | Eight-year trends in the relative isolation frequency and antimicrobial susceptibility among bloodstream isolates from Greek hospitals: data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance – WHONET-Greece, 2010 to 2017 |
| title_short | Eight-year trends in the relative isolation frequency and antimicrobial susceptibility among bloodstream isolates from Greek hospitals: data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance – WHONET-Greece, 2010 to 2017 |
| title_sort | eight-year trends in the relative isolation frequency and antimicrobial susceptibility among bloodstream isolates from greek hospitals: data from the greek electronic system for the surveillance of antimicrobial resistance – whonet-greece, 2010 to 2017 |
| topic | Surveillance |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453683/ https://www.ncbi.nlm.nih.gov/pubmed/32856583 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.34.1900516 |
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