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Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder
Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spe...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453794/ https://www.ncbi.nlm.nih.gov/pubmed/32762791 http://dx.doi.org/10.1192/bjo.2020.71 |
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author | Gouveia, Flavia Venetucci Germann, Jürgen Devenyi, Gabriel A. Morais, Rosa M. C. B. Santos, Ana Paula M. Fonoff, Erich T. Hamani, Clement Brentani, Helena Chakravarty, M. Mallar Martinez, Raquel C. R. |
author_facet | Gouveia, Flavia Venetucci Germann, Jürgen Devenyi, Gabriel A. Morais, Rosa M. C. B. Santos, Ana Paula M. Fonoff, Erich T. Hamani, Clement Brentani, Helena Chakravarty, M. Mallar Martinez, Raquel C. R. |
author_sort | Gouveia, Flavia Venetucci |
collection | PubMed |
description | Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spectrum disorder with pharmacological-treatment-refractory aggressive behaviour compared with those with non-refractory aggressive behaviour and observed a brain-wide pattern of local increased thickness in key areas related to emotional control and overall decreased cortical thickness in those with refractory aggressive behaviour, suggesting refractoriness could be related to specific morphological patterns. Elucidating the neurobiology of refractory aggressive behaviour is crucial to provide insights and potential avenues for new interventions. |
format | Online Article Text |
id | pubmed-7453794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74537942020-09-11 Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder Gouveia, Flavia Venetucci Germann, Jürgen Devenyi, Gabriel A. Morais, Rosa M. C. B. Santos, Ana Paula M. Fonoff, Erich T. Hamani, Clement Brentani, Helena Chakravarty, M. Mallar Martinez, Raquel C. R. BJPsych Open Short Report Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spectrum disorder with pharmacological-treatment-refractory aggressive behaviour compared with those with non-refractory aggressive behaviour and observed a brain-wide pattern of local increased thickness in key areas related to emotional control and overall decreased cortical thickness in those with refractory aggressive behaviour, suggesting refractoriness could be related to specific morphological patterns. Elucidating the neurobiology of refractory aggressive behaviour is crucial to provide insights and potential avenues for new interventions. Cambridge University Press 2020-08-07 /pmc/articles/PMC7453794/ /pubmed/32762791 http://dx.doi.org/10.1192/bjo.2020.71 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Gouveia, Flavia Venetucci Germann, Jürgen Devenyi, Gabriel A. Morais, Rosa M. C. B. Santos, Ana Paula M. Fonoff, Erich T. Hamani, Clement Brentani, Helena Chakravarty, M. Mallar Martinez, Raquel C. R. Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder |
title | Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder |
title_full | Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder |
title_fullStr | Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder |
title_full_unstemmed | Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder |
title_short | Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder |
title_sort | refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453794/ https://www.ncbi.nlm.nih.gov/pubmed/32762791 http://dx.doi.org/10.1192/bjo.2020.71 |
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