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Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder

Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spe...

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Autores principales: Gouveia, Flavia Venetucci, Germann, Jürgen, Devenyi, Gabriel A., Morais, Rosa M. C. B., Santos, Ana Paula M., Fonoff, Erich T., Hamani, Clement, Brentani, Helena, Chakravarty, M. Mallar, Martinez, Raquel C. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453794/
https://www.ncbi.nlm.nih.gov/pubmed/32762791
http://dx.doi.org/10.1192/bjo.2020.71
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author Gouveia, Flavia Venetucci
Germann, Jürgen
Devenyi, Gabriel A.
Morais, Rosa M. C. B.
Santos, Ana Paula M.
Fonoff, Erich T.
Hamani, Clement
Brentani, Helena
Chakravarty, M. Mallar
Martinez, Raquel C. R.
author_facet Gouveia, Flavia Venetucci
Germann, Jürgen
Devenyi, Gabriel A.
Morais, Rosa M. C. B.
Santos, Ana Paula M.
Fonoff, Erich T.
Hamani, Clement
Brentani, Helena
Chakravarty, M. Mallar
Martinez, Raquel C. R.
author_sort Gouveia, Flavia Venetucci
collection PubMed
description Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spectrum disorder with pharmacological-treatment-refractory aggressive behaviour compared with those with non-refractory aggressive behaviour and observed a brain-wide pattern of local increased thickness in key areas related to emotional control and overall decreased cortical thickness in those with refractory aggressive behaviour, suggesting refractoriness could be related to specific morphological patterns. Elucidating the neurobiology of refractory aggressive behaviour is crucial to provide insights and potential avenues for new interventions.
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spelling pubmed-74537942020-09-11 Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder Gouveia, Flavia Venetucci Germann, Jürgen Devenyi, Gabriel A. Morais, Rosa M. C. B. Santos, Ana Paula M. Fonoff, Erich T. Hamani, Clement Brentani, Helena Chakravarty, M. Mallar Martinez, Raquel C. R. BJPsych Open Short Report Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spectrum disorder with pharmacological-treatment-refractory aggressive behaviour compared with those with non-refractory aggressive behaviour and observed a brain-wide pattern of local increased thickness in key areas related to emotional control and overall decreased cortical thickness in those with refractory aggressive behaviour, suggesting refractoriness could be related to specific morphological patterns. Elucidating the neurobiology of refractory aggressive behaviour is crucial to provide insights and potential avenues for new interventions. Cambridge University Press 2020-08-07 /pmc/articles/PMC7453794/ /pubmed/32762791 http://dx.doi.org/10.1192/bjo.2020.71 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Gouveia, Flavia Venetucci
Germann, Jürgen
Devenyi, Gabriel A.
Morais, Rosa M. C. B.
Santos, Ana Paula M.
Fonoff, Erich T.
Hamani, Clement
Brentani, Helena
Chakravarty, M. Mallar
Martinez, Raquel C. R.
Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder
title Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder
title_full Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder
title_fullStr Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder
title_full_unstemmed Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder
title_short Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder
title_sort refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453794/
https://www.ncbi.nlm.nih.gov/pubmed/32762791
http://dx.doi.org/10.1192/bjo.2020.71
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