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Association between Maternal Serum Homocysteine Concentrations in Early Pregnancy and Adverse Pregnancy Outcomes
BACKGROUND: There is still conflicting evidence on the extent to which maternal hyperhomocysteinemia is a risk factor for pregnancy complications. AIMS: The study aimed to investigate the impact of elevated maternal homocysteine concentrations on adverse pregnancy outcomes among Nigerian women in La...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453941/ https://www.ncbi.nlm.nih.gov/pubmed/32499467 http://dx.doi.org/10.4103/aam.aam_41_19 |
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author | Nwogu, Chidinma Magnus Okunade, Kehinde Sharafadeen Adenekan, Muisi A. Sekumade, Adebayo Isaiah John-olabode, Sarah Oluwole, Ayodeji Ayotunde |
author_facet | Nwogu, Chidinma Magnus Okunade, Kehinde Sharafadeen Adenekan, Muisi A. Sekumade, Adebayo Isaiah John-olabode, Sarah Oluwole, Ayodeji Ayotunde |
author_sort | Nwogu, Chidinma Magnus |
collection | PubMed |
description | BACKGROUND: There is still conflicting evidence on the extent to which maternal hyperhomocysteinemia is a risk factor for pregnancy complications. AIMS: The study aimed to investigate the impact of elevated maternal homocysteine concentrations on adverse pregnancy outcomes among Nigerian women in Lagos. MATERIALS AND METHODS: This was a prospective cohort study conducted at the Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria. Participants were enrolled during the first trimester of pregnancy following which relevant data were obtained by the interview. Fasting blood samples were collected for the measurement of maternal homocysteine concentration using the enzyme-linked immunosorbent assay method. Pregnancy outcomes and complications were obtained by abstracting the antenatal, delivery, and newborn medical records. Preterm births, low-birth weight (LBW), and antepartum fetal death were used as confirmatory outcome variables in the final analysis. Descriptive statistics for all data were computed using SPSS version 22.0. The associations between the variables were tested and multivariate analyses were used to study the effects of the major baseline characteristics on the pregnancy outcome. P < 0.05 was considered statistically significant. RESULTS: Hyperhomocysteinemia was recorded in 41 (24.6%) patients. Women with a high homocysteine concentration and those with a normal homocysteine level did not differ significantly in terms of age (P = 0.684), level of education (P = 0.866), and parity (P = 0.647). Women with hyperhomocysteinemia had an approximately twelve-fold higher risk of preterm birth (P = 0.001) and a ten-fold higher risk of delivering a term neonate with LBW (P = 0.004), but had no risk of antepartum fetal death (P = 0.118) compared to women with a normal homocysteine concentration. CONCLUSIONS: The prevalence of hyperhomocysteinemia among mothers in Lagos was relatively low. The associations between hyperhomocysteinemia and adverse pregnancy outcomes could have implications in future for the prevention of these adverse outcomes. |
format | Online Article Text |
id | pubmed-7453941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-74539412020-09-03 Association between Maternal Serum Homocysteine Concentrations in Early Pregnancy and Adverse Pregnancy Outcomes Nwogu, Chidinma Magnus Okunade, Kehinde Sharafadeen Adenekan, Muisi A. Sekumade, Adebayo Isaiah John-olabode, Sarah Oluwole, Ayodeji Ayotunde Ann Afr Med Original Article BACKGROUND: There is still conflicting evidence on the extent to which maternal hyperhomocysteinemia is a risk factor for pregnancy complications. AIMS: The study aimed to investigate the impact of elevated maternal homocysteine concentrations on adverse pregnancy outcomes among Nigerian women in Lagos. MATERIALS AND METHODS: This was a prospective cohort study conducted at the Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria. Participants were enrolled during the first trimester of pregnancy following which relevant data were obtained by the interview. Fasting blood samples were collected for the measurement of maternal homocysteine concentration using the enzyme-linked immunosorbent assay method. Pregnancy outcomes and complications were obtained by abstracting the antenatal, delivery, and newborn medical records. Preterm births, low-birth weight (LBW), and antepartum fetal death were used as confirmatory outcome variables in the final analysis. Descriptive statistics for all data were computed using SPSS version 22.0. The associations between the variables were tested and multivariate analyses were used to study the effects of the major baseline characteristics on the pregnancy outcome. P < 0.05 was considered statistically significant. RESULTS: Hyperhomocysteinemia was recorded in 41 (24.6%) patients. Women with a high homocysteine concentration and those with a normal homocysteine level did not differ significantly in terms of age (P = 0.684), level of education (P = 0.866), and parity (P = 0.647). Women with hyperhomocysteinemia had an approximately twelve-fold higher risk of preterm birth (P = 0.001) and a ten-fold higher risk of delivering a term neonate with LBW (P = 0.004), but had no risk of antepartum fetal death (P = 0.118) compared to women with a normal homocysteine concentration. CONCLUSIONS: The prevalence of hyperhomocysteinemia among mothers in Lagos was relatively low. The associations between hyperhomocysteinemia and adverse pregnancy outcomes could have implications in future for the prevention of these adverse outcomes. Wolters Kluwer - Medknow 2020 2020-06-03 /pmc/articles/PMC7453941/ /pubmed/32499467 http://dx.doi.org/10.4103/aam.aam_41_19 Text en Copyright: © 2020 Annals of African Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Nwogu, Chidinma Magnus Okunade, Kehinde Sharafadeen Adenekan, Muisi A. Sekumade, Adebayo Isaiah John-olabode, Sarah Oluwole, Ayodeji Ayotunde Association between Maternal Serum Homocysteine Concentrations in Early Pregnancy and Adverse Pregnancy Outcomes |
title | Association between Maternal Serum Homocysteine Concentrations in Early Pregnancy and Adverse Pregnancy Outcomes |
title_full | Association between Maternal Serum Homocysteine Concentrations in Early Pregnancy and Adverse Pregnancy Outcomes |
title_fullStr | Association between Maternal Serum Homocysteine Concentrations in Early Pregnancy and Adverse Pregnancy Outcomes |
title_full_unstemmed | Association between Maternal Serum Homocysteine Concentrations in Early Pregnancy and Adverse Pregnancy Outcomes |
title_short | Association between Maternal Serum Homocysteine Concentrations in Early Pregnancy and Adverse Pregnancy Outcomes |
title_sort | association between maternal serum homocysteine concentrations in early pregnancy and adverse pregnancy outcomes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453941/ https://www.ncbi.nlm.nih.gov/pubmed/32499467 http://dx.doi.org/10.4103/aam.aam_41_19 |
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