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Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer

Previous studies found patients with POLE exonuclease domain mutations (EDMs) in targeted exons were related to significant better outcomes in stage II-III colorectal cancer (CRC). The detailed mutational profile of the entire POLE exonuclease domain, tumor mutation burden (TMB) and immune cell infi...

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Detalles Bibliográficos
Autores principales:	Mo, Shaobo, Ma, Xiaoji, Li, Yaqi, Zhang, Long, Hou, Ting, Han-Zhang, Han, Qian, Juanjuan, Cai, Sanjun, Huang, Dan, Peng, Junjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Immunotherapy Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454238/ https://www.ncbi.nlm.nih.gov/pubmed/32859741 http://dx.doi.org/10.1136/jitc-2020-000881

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