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The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study
BACKGROUND: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. METHODS: This is a prospective, observational, multicentre, longitudinal, cohort study with...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454350/ https://www.ncbi.nlm.nih.gov/pubmed/32702087 http://dx.doi.org/10.1093/cvr/cvaa209 |
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author | Mangion, Kenneth Morrow, Andrew Bagot, Catherine Bayes, Hannah Blyth, Kevin G Church, Colin Corcoran, David Delles, Christian Gillespie, Lynsey Grieve, Douglas Ho, Antonia Kean, Sharon Lang, Ninian N Lennie, Vera Lowe, David J Kellman, Peter Macfarlane, Peter W McConnachie, Alex Roditi, Giles Sykes, Robert Touyz, Rhian M Sattar, Naveed Wereski, Ryan Wright, Sylvia Berry, Colin |
author_facet | Mangion, Kenneth Morrow, Andrew Bagot, Catherine Bayes, Hannah Blyth, Kevin G Church, Colin Corcoran, David Delles, Christian Gillespie, Lynsey Grieve, Douglas Ho, Antonia Kean, Sharon Lang, Ninian N Lennie, Vera Lowe, David J Kellman, Peter Macfarlane, Peter W McConnachie, Alex Roditi, Giles Sykes, Robert Touyz, Rhian M Sattar, Naveed Wereski, Ryan Wright, Sylvia Berry, Colin |
author_sort | Mangion, Kenneth |
collection | PubMed |
description | BACKGROUND: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. METHODS: This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation. CONCLUSION: CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT04403607. |
format | Online Article Text |
id | pubmed-7454350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74543502020-08-31 The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study Mangion, Kenneth Morrow, Andrew Bagot, Catherine Bayes, Hannah Blyth, Kevin G Church, Colin Corcoran, David Delles, Christian Gillespie, Lynsey Grieve, Douglas Ho, Antonia Kean, Sharon Lang, Ninian N Lennie, Vera Lowe, David J Kellman, Peter Macfarlane, Peter W McConnachie, Alex Roditi, Giles Sykes, Robert Touyz, Rhian M Sattar, Naveed Wereski, Ryan Wright, Sylvia Berry, Colin Cardiovasc Res Reviews BACKGROUND: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. METHODS: This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation. CONCLUSION: CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT04403607. Oxford University Press 2020-07-23 /pmc/articles/PMC7454350/ /pubmed/32702087 http://dx.doi.org/10.1093/cvr/cvaa209 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Mangion, Kenneth Morrow, Andrew Bagot, Catherine Bayes, Hannah Blyth, Kevin G Church, Colin Corcoran, David Delles, Christian Gillespie, Lynsey Grieve, Douglas Ho, Antonia Kean, Sharon Lang, Ninian N Lennie, Vera Lowe, David J Kellman, Peter Macfarlane, Peter W McConnachie, Alex Roditi, Giles Sykes, Robert Touyz, Rhian M Sattar, Naveed Wereski, Ryan Wright, Sylvia Berry, Colin The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study |
title | The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study |
title_full | The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study |
title_fullStr | The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study |
title_full_unstemmed | The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study |
title_short | The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study |
title_sort | chief scientist office cardiovascular and pulmonary imaging in sars coronavirus disease-19 (cisco-19) study |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454350/ https://www.ncbi.nlm.nih.gov/pubmed/32702087 http://dx.doi.org/10.1093/cvr/cvaa209 |
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