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The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study

BACKGROUND: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. METHODS: This is a prospective, observational, multicentre, longitudinal, cohort study with...

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Autores principales: Mangion, Kenneth, Morrow, Andrew, Bagot, Catherine, Bayes, Hannah, Blyth, Kevin G, Church, Colin, Corcoran, David, Delles, Christian, Gillespie, Lynsey, Grieve, Douglas, Ho, Antonia, Kean, Sharon, Lang, Ninian N, Lennie, Vera, Lowe, David J, Kellman, Peter, Macfarlane, Peter W, McConnachie, Alex, Roditi, Giles, Sykes, Robert, Touyz, Rhian M, Sattar, Naveed, Wereski, Ryan, Wright, Sylvia, Berry, Colin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454350/
https://www.ncbi.nlm.nih.gov/pubmed/32702087
http://dx.doi.org/10.1093/cvr/cvaa209
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author Mangion, Kenneth
Morrow, Andrew
Bagot, Catherine
Bayes, Hannah
Blyth, Kevin G
Church, Colin
Corcoran, David
Delles, Christian
Gillespie, Lynsey
Grieve, Douglas
Ho, Antonia
Kean, Sharon
Lang, Ninian N
Lennie, Vera
Lowe, David J
Kellman, Peter
Macfarlane, Peter W
McConnachie, Alex
Roditi, Giles
Sykes, Robert
Touyz, Rhian M
Sattar, Naveed
Wereski, Ryan
Wright, Sylvia
Berry, Colin
author_facet Mangion, Kenneth
Morrow, Andrew
Bagot, Catherine
Bayes, Hannah
Blyth, Kevin G
Church, Colin
Corcoran, David
Delles, Christian
Gillespie, Lynsey
Grieve, Douglas
Ho, Antonia
Kean, Sharon
Lang, Ninian N
Lennie, Vera
Lowe, David J
Kellman, Peter
Macfarlane, Peter W
McConnachie, Alex
Roditi, Giles
Sykes, Robert
Touyz, Rhian M
Sattar, Naveed
Wereski, Ryan
Wright, Sylvia
Berry, Colin
author_sort Mangion, Kenneth
collection PubMed
description BACKGROUND: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. METHODS: This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation. CONCLUSION: CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT04403607.
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spelling pubmed-74543502020-08-31 The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study Mangion, Kenneth Morrow, Andrew Bagot, Catherine Bayes, Hannah Blyth, Kevin G Church, Colin Corcoran, David Delles, Christian Gillespie, Lynsey Grieve, Douglas Ho, Antonia Kean, Sharon Lang, Ninian N Lennie, Vera Lowe, David J Kellman, Peter Macfarlane, Peter W McConnachie, Alex Roditi, Giles Sykes, Robert Touyz, Rhian M Sattar, Naveed Wereski, Ryan Wright, Sylvia Berry, Colin Cardiovasc Res Reviews BACKGROUND: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. METHODS: This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation. CONCLUSION: CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT04403607. Oxford University Press 2020-07-23 /pmc/articles/PMC7454350/ /pubmed/32702087 http://dx.doi.org/10.1093/cvr/cvaa209 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Mangion, Kenneth
Morrow, Andrew
Bagot, Catherine
Bayes, Hannah
Blyth, Kevin G
Church, Colin
Corcoran, David
Delles, Christian
Gillespie, Lynsey
Grieve, Douglas
Ho, Antonia
Kean, Sharon
Lang, Ninian N
Lennie, Vera
Lowe, David J
Kellman, Peter
Macfarlane, Peter W
McConnachie, Alex
Roditi, Giles
Sykes, Robert
Touyz, Rhian M
Sattar, Naveed
Wereski, Ryan
Wright, Sylvia
Berry, Colin
The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study
title The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study
title_full The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study
title_fullStr The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study
title_full_unstemmed The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study
title_short The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study
title_sort chief scientist office cardiovascular and pulmonary imaging in sars coronavirus disease-19 (cisco-19) study
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454350/
https://www.ncbi.nlm.nih.gov/pubmed/32702087
http://dx.doi.org/10.1093/cvr/cvaa209
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