Endocrine Significance of SARS-CoV-2’s Reliance on ACE2

The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to...

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Autores principales: Lazartigues, Eric, Qadir, Mirza Muhammad Fahd, Mauvais-Jarvis, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Mini-Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454499/
https://www.ncbi.nlm.nih.gov/pubmed/32652001
http://dx.doi.org/10.1210/endocr/bqaa108
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author Lazartigues, Eric
Qadir, Mirza Muhammad Fahd
Mauvais-Jarvis, Franck
author_facet Lazartigues, Eric
Qadir, Mirza Muhammad Fahd
Mauvais-Jarvis, Franck
author_sort Lazartigues, Eric
collection PubMed
description The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases.
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spelling pubmed-74544992020-08-31 Endocrine Significance of SARS-CoV-2’s Reliance on ACE2 Lazartigues, Eric Qadir, Mirza Muhammad Fahd Mauvais-Jarvis, Franck Endocrinology Mini-Reviews The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases. Oxford University Press 2020-07-11 /pmc/articles/PMC7454499/ /pubmed/32652001 http://dx.doi.org/10.1210/endocr/bqaa108 Text en © Endocrine Society 2020. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Reviews
Lazartigues, Eric
Qadir, Mirza Muhammad Fahd
Mauvais-Jarvis, Franck
Endocrine Significance of SARS-CoV-2’s Reliance on ACE2
title Endocrine Significance of SARS-CoV-2’s Reliance on ACE2
title_full Endocrine Significance of SARS-CoV-2’s Reliance on ACE2
title_fullStr Endocrine Significance of SARS-CoV-2’s Reliance on ACE2
title_full_unstemmed Endocrine Significance of SARS-CoV-2’s Reliance on ACE2
title_short Endocrine Significance of SARS-CoV-2’s Reliance on ACE2
title_sort endocrine significance of sars-cov-2’s reliance on ace2
topic Mini-Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454499/
https://www.ncbi.nlm.nih.gov/pubmed/32652001
http://dx.doi.org/10.1210/endocr/bqaa108
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AT mauvaisjarvisfranck endocrinesignificanceofsarscov2srelianceonace2

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