Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques

Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia...

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Autores principales: Koo, Bon-Sang, Oh, Hanseul, Kim, Green, Hwang, Eun-Ha, Jung, Hoyin, Lee, Youngjeon, Kang, Philyong, Park, Jae-Hak, Ryu, Choong-Min, Hong, Jung Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454693/
https://www.ncbi.nlm.nih.gov/pubmed/32745172
http://dx.doi.org/10.1093/infdis/jiaa486
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author Koo, Bon-Sang
Oh, Hanseul
Kim, Green
Hwang, Eun-Ha
Jung, Hoyin
Lee, Youngjeon
Kang, Philyong
Park, Jae-Hak
Ryu, Choong-Min
Hong, Jung Joo
author_facet Koo, Bon-Sang
Oh, Hanseul
Kim, Green
Hwang, Eun-Ha
Jung, Hoyin
Lee, Youngjeon
Kang, Philyong
Park, Jae-Hak
Ryu, Choong-Min
Hong, Jung Joo
author_sort Koo, Bon-Sang
collection PubMed
description Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.
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spelling pubmed-74546932020-08-31 Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques Koo, Bon-Sang Oh, Hanseul Kim, Green Hwang, Eun-Ha Jung, Hoyin Lee, Youngjeon Kang, Philyong Park, Jae-Hak Ryu, Choong-Min Hong, Jung Joo J Infect Dis Major Articles and Brief Reports Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies. Oxford University Press 2020-08-03 /pmc/articles/PMC7454693/ /pubmed/32745172 http://dx.doi.org/10.1093/infdis/jiaa486 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles and Brief Reports
Koo, Bon-Sang
Oh, Hanseul
Kim, Green
Hwang, Eun-Ha
Jung, Hoyin
Lee, Youngjeon
Kang, Philyong
Park, Jae-Hak
Ryu, Choong-Min
Hong, Jung Joo
Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques
title Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques
title_full Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques
title_fullStr Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques
title_full_unstemmed Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques
title_short Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques
title_sort transient lymphopenia and interstitial pneumonia with endotheliitis in sars-cov-2–infected macaques
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454693/
https://www.ncbi.nlm.nih.gov/pubmed/32745172
http://dx.doi.org/10.1093/infdis/jiaa486
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