C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling

Critical illness is accompanied by the release of large amounts of the anaphylotoxin, C5a. C5a suppresses antimicrobial functions of neutrophils which is associated with adverse outcomes. The signaling pathways that mediate C5a-induced neutrophil dysfunction are incompletely understood. Healthy dono...

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Detalles Bibliográficos
Autores principales: Wood, Alexander J.T., Vassallo, Arlette M., Ruchaud-Sparagano, Marie-Hélène, Scott, Jonathan, Zinnato, Carmelo, Gonzalez-Tejedo, Carmen, Kishore, Kamal, D’Santos, Clive S., Simpson, A. John, Menon, David K., Summers, Charlotte, Chilvers, Edwin R., Okkenhaug, Klaus, Morris, Andrew Conway
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455072/
https://www.ncbi.nlm.nih.gov/pubmed/32634128
http://dx.doi.org/10.1172/jci.insight.137029

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