CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation

Metabolic reprogramming dictates the fate and function of stimulated T cells, yet these pathways can be suppressed in T cells in tumor microenvironments. We previously showed that glycolytic and mitochondrial adaptations directly contribute to reducing the effector function of renal cell carcinoma (...

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Detalles Bibliográficos
Autores principales: Beckermann, Kathryn E., Hongo, Rachel, Ye, Xiang, Young, Kirsten, Carbonell, Katie, Healey, Diana C. Contreras, Siska, Peter J., Barone, Sierra, Roe, Caroline E., Smith, Christof C., Vincent, Benjamin G., Mason, Frank M., Irish, Jonathan M., Rathmell, W. Kimryn, Rathmell, Jeffrey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455120/
https://www.ncbi.nlm.nih.gov/pubmed/32814710
http://dx.doi.org/10.1172/jci.insight.138729

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