Cargando…

Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation

BACKGROUND: Genomic and experimental studies suggest a role for PITX2 in atrial fibrillation (AF). To assess if this association is relevant for recurrent AF in patients, we tested whether left atrial PITX2 affects recurrent AF after AF ablation. METHODS: mRNA concentrations of PITX2 and its cardiac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reyat, Jasmeet S., Chua, Winnie, Cardoso, Victor R., Witten, Anika, Kastner, Peter M., Kabir, S. Nashitha, Sinner, Moritz F., Wesselink, Robin, Holmes, Andrew P., Pavlovic, Davor, Stoll, Monika, Kääb, Stefan, Gkoutos, Georgios V., de Groot, Joris R., Kirchhof, Paulus, Fabritz, Larissa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2020
Materias:	Clinical Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455124/ https://www.ncbi.nlm.nih.gov/pubmed/32814717 http://dx.doi.org/10.1172/jci.insight.139179

Ejemplares similares

PITX2‐dependent gene regulation in atrial fibrillation and rhythm control
por: Syeda, Fahima, et al.
Publicado: (2017)

Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone
por: Holmes, Andrew P., et al.
Publicado: (2021)

An angiopoietin 2, FGF23, and BMP10 biomarker signature differentiates atrial fibrillation from other concomitant cardiovascular conditions
por: Chua, Winnie, et al.
Publicado: (2023)

PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers
por: Syeda, Fahima, et al.
Publicado: (2016)

Heart failure, female sex and atrial fibrillation are the main drivers of atrial cardiomyopathy in cardiac surgery patients: results from the CATCH ME consortium
por: Winters, J, et al.
Publicado: (2023)

The RACE-3 is on: double-locking sinus rhythm by upstream and downstream therapy
por: Pavlovic, Davor, et al.
Publicado: (2018)

Etiological and molecular determinants of atrial endomysial fibrosis: results from the CATCH ME consortium
por: Winters, J, et al.
Publicado: (2023)

An Introduction to Murine Models of Atrial Fibrillation
por: Riley, Genna, et al.
Publicado: (2012)

Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank
por: Kany, Shinwan, et al.
Publicado: (2022)

Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: A validation study
por: Chua, Winnie, et al.
Publicado: (2021)

Cardiac optical mapping – State-of-the-art and future challenges
por: O’Shea, Christopher, et al.
Publicado: (2020)

Data-driven discovery and validation of circulating blood-based biomarkers associated with prevalent atrial fibrillation
por: Chua, Winnie, et al.
Publicado: (2019)

Development and external validation of predictive models for prevalent and recurrent atrial fibrillation: a protocol for the analysis of the CATCH ME combined dataset
por: Chua, Winnie, et al.
Publicado: (2019)

Prognostic models for predicting incident or recurrent atrial fibrillation: protocol for a systematic review
por: Dretzke, Janine, et al.
Publicado: (2019)

High resolution optical mapping of cardiac electrophysiology in pre-clinical models
por: O’Shea, Christopher, et al.
Publicado: (2022)

Integrated care of patients with atrial fibrillation: the 2016 ESC atrial fibrillation guidelines
por: Kirchhof, Paulus
Publicado: (2017)

Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide
por: O’Reilly, Molly, et al.
Publicado: (2022)

Transgenic Insights Linking Pitx2 and Atrial Arrhythmias
por: Franco, Diego, et al.
Publicado: (2012)

European Society of Cardiology smartphone and tablet applications for patients with atrial fibrillation and their health care providers
por: Kotecha, Dipak, et al.
Publicado: (2018)

Effects of hydroxychloroquine on atrial electrophysiology in in silico wild-type and PITX2(+/-) atrial cardiomyocytes
por: Song, Euijun
Publicado: (2023)

Detection of unknown atrial fibrillation by prolonged ECG monitoring in an all-comer patient cohort and association with clinical and Holter variables
por: Jawad-Ul-Qamar, Muhammad, et al.
Publicado: (2020)

Predicting recurrent atrial fibrillation after catheter ablation: a systematic review of prognostic models
por: Dretzke, Janine, et al.
Publicado: (2020)

A Regional Reduction in I(to) and I(KACh) in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity
por: Holmes, Andrew P., et al.
Publicado: (2016)

Decoding the PITX2-controlled genetic network in atrial fibrillation
por: Steimle, Jeffrey D., et al.
Publicado: (2022)

Catheter ablation in patients with persistent atrial fibrillation
por: Kirchhof, Paulus, et al.
Publicado: (2017)

Incidence of complications related to catheter ablation of atrial fibrillation and atrial flutter: a nationwide in-hospital analysis of administrative data for Germany in 2014
por: Steinbeck, Gerhard, et al.
Publicado: (2018)

PITX2C loss-of-function mutations responsible for idiopathic atrial fibrillation
por: Qiu, Xing-Biao, et al.
Publicado: (2014)

In silico investigation of the mechanisms underlying atrial fibrillation due to impaired Pitx2
por: Bai, Jieyun, et al.
Publicado: (2020)

Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models
por: Bai, Jieyun, et al.
Publicado: (2021)

PITX2c impairment electrical remodeling increases susceptibility to atrial fibrillation
por: Mun, D S, et al.
Publicado: (2023)

Almanac 2015: atrial fibrillation research in Heart
por: Jawad-Ul-Qamar, Muhammad, et al.
Publicado: (2016)

Recent advances in rhythm control for atrial fibrillation
por: Bond, Richard, et al.
Publicado: (2017)

Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5
por: Kloosterman, Mariëlle, et al.
Publicado: (2020)

PITX2c Loss-of-Function Mutations Responsible for Congenital Atrial Septal Defects
por: Yuan, Fang, et al.
Publicado: (2013)

Association Between rs2200733 Polymorphism of PITX2 Gene and the Risk of Atrial Fibrillation
por: Shen Han, Yin, et al.
Publicado: (2023)

Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death
por: Brady, Paul F., et al.
Publicado: (2022)

Self-palpation for detection of paroxysmal atrial fibrillation: Much noise with little signal
por: Rahimi, Kazem, et al.
Publicado: (2020)

Systematic Analysis of Gene Expression Differences between Left and Right Atria in Different Mouse Strains and in Human Atrial Tissue
por: Kahr, Peter C., et al.
Publicado: (2011)

PITX2 gain-of-function mutation associated with atrial fibrillation alters mitochondrial activity in human iPSC atrial-like cardiomyocytes
por: Benzoni, Patrizia, et al.
Publicado: (2023)

Temporal irregularity quantification and mapping of optical action potentials using wave morphology similarity
por: O’Shea, Christopher, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gp15b1eqgkl3d5258auceh9ifd