Kynurenines link chronic inflammation to functional decline and physical frailty

Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms of this linkage are not understood. A mouse model of chronic inflammation showed reduced motor function and partial denervation at the neuromuscular junction. Metabolomi...

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Detalles Bibliográficos
Autores principales: Westbrook, Reyhan, Chung, Tae, Lovett, Jacqueline, Ward, Chris, Joca, Humberto, Yang, Huanle, Khadeer, Mohammed, Tian, Jing, Xue, Qian-Li, Le, Anne, Ferrucci, Luigi, Moaddel, Ruin, de Cabo, Rafa, Hoke, Ahmet, Walston, Jeremy, Abadir, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455140/
https://www.ncbi.nlm.nih.gov/pubmed/32814718
http://dx.doi.org/10.1172/jci.insight.136091

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