Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration

The regulatory mechanisms enabling the intestinal epithelium to maintain a high degree of regenerative capacity during mucosal injury remain unclear. Ex vivo survival and clonogenicity of intestinal stem cells (ISCs) strictly required growth response mediated by cell division control 42 (Cdc42) and...

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Detalles Bibliográficos
Autores principales: Zhang, Xiao, Bandyopadhyay, Sheila, Araujo, Leandro Pires, Tong, Kevin, Flores, Juan, Laubitz, Daniel, Zhao, Yanlin, Yap, George, Wang, Jingren, Zou, Qingze, Ferraris, Ronaldo, Zhang, Lanjing, Hu, Wenwei, Bonder, Edward M., Kiela, Pawel R., Coffey, Robert, Verzi, Michael P., Ivanov, Ivaylo I., Gao, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455142/
https://www.ncbi.nlm.nih.gov/pubmed/32686657
http://dx.doi.org/10.1172/jci.insight.135923

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