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Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion
Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We present a system with this type of functionality in which the constituent...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455185/ https://www.ncbi.nlm.nih.gov/pubmed/32923633 http://dx.doi.org/10.1126/sciadv.abb1093 |
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author | Koo, Jahyun Kim, Sung Bong Choi, Yeon Sik Xie, Zhaoqian Bandodkar, Amay J. Khalifeh, Jawad Yan, Ying Kim, Hojun Pezhouh, Maryam Kherad Doty, Karen Lee, Geumbee Chen, Yu-Yu Lee, Seung Min D’Andrea, Dominic Jung, Kimin Lee, KunHyuck Li, Kan Jo, Seongbin Wang, Heling Kim, Jae-Hwan Kim, Jeonghyun Choi, Sung-Geun Jang, Woo Jin Oh, Yong Suk Park, Inkyu Kwak, Sung Soo Park, Ji-Hyeon Hong, Doosun Feng, Xue Lee, Chi-Hwan Banks, Anthony Leal, Cecilia Lee, Hyuck Mo Huang, Yonggang Franz, Colin K. Ray, Wilson Z. MacEwan, Matthew Kang, Seung-Kyun Rogers, John A. |
author_facet | Koo, Jahyun Kim, Sung Bong Choi, Yeon Sik Xie, Zhaoqian Bandodkar, Amay J. Khalifeh, Jawad Yan, Ying Kim, Hojun Pezhouh, Maryam Kherad Doty, Karen Lee, Geumbee Chen, Yu-Yu Lee, Seung Min D’Andrea, Dominic Jung, Kimin Lee, KunHyuck Li, Kan Jo, Seongbin Wang, Heling Kim, Jae-Hwan Kim, Jeonghyun Choi, Sung-Geun Jang, Woo Jin Oh, Yong Suk Park, Inkyu Kwak, Sung Soo Park, Ji-Hyeon Hong, Doosun Feng, Xue Lee, Chi-Hwan Banks, Anthony Leal, Cecilia Lee, Hyuck Mo Huang, Yonggang Franz, Colin K. Ray, Wilson Z. MacEwan, Matthew Kang, Seung-Kyun Rogers, John A. |
author_sort | Koo, Jahyun |
collection | PubMed |
description | Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We present a system with this type of functionality in which the constituent materials undergo complete bioresorption to eliminate device load from the patient after completing the final stage of the release process. Here, bioresorbable polyanhydride reservoirs store drugs in defined reservoirs without leakage until wirelessly triggered valve structures open to allow release. These valves operate through an electrochemical mechanism of geometrically accelerated corrosion induced by passage of electrical current from a wireless, bioresorbable power-harvesting unit. Evaluations in cell cultures demonstrate the efficacy of this technology for the treatment of cancerous tissues by release of the drug doxorubicin. Complete in vivo studies of platforms with multiple, independently controlled release events in live-animal models illustrate capabilities for control of blood glucose levels by timed delivery of insulin. |
format | Online Article Text |
id | pubmed-7455185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74551852020-09-11 Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion Koo, Jahyun Kim, Sung Bong Choi, Yeon Sik Xie, Zhaoqian Bandodkar, Amay J. Khalifeh, Jawad Yan, Ying Kim, Hojun Pezhouh, Maryam Kherad Doty, Karen Lee, Geumbee Chen, Yu-Yu Lee, Seung Min D’Andrea, Dominic Jung, Kimin Lee, KunHyuck Li, Kan Jo, Seongbin Wang, Heling Kim, Jae-Hwan Kim, Jeonghyun Choi, Sung-Geun Jang, Woo Jin Oh, Yong Suk Park, Inkyu Kwak, Sung Soo Park, Ji-Hyeon Hong, Doosun Feng, Xue Lee, Chi-Hwan Banks, Anthony Leal, Cecilia Lee, Hyuck Mo Huang, Yonggang Franz, Colin K. Ray, Wilson Z. MacEwan, Matthew Kang, Seung-Kyun Rogers, John A. Sci Adv Research Articles Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We present a system with this type of functionality in which the constituent materials undergo complete bioresorption to eliminate device load from the patient after completing the final stage of the release process. Here, bioresorbable polyanhydride reservoirs store drugs in defined reservoirs without leakage until wirelessly triggered valve structures open to allow release. These valves operate through an electrochemical mechanism of geometrically accelerated corrosion induced by passage of electrical current from a wireless, bioresorbable power-harvesting unit. Evaluations in cell cultures demonstrate the efficacy of this technology for the treatment of cancerous tissues by release of the drug doxorubicin. Complete in vivo studies of platforms with multiple, independently controlled release events in live-animal models illustrate capabilities for control of blood glucose levels by timed delivery of insulin. American Association for the Advancement of Science 2020-08-28 /pmc/articles/PMC7455185/ /pubmed/32923633 http://dx.doi.org/10.1126/sciadv.abb1093 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Koo, Jahyun Kim, Sung Bong Choi, Yeon Sik Xie, Zhaoqian Bandodkar, Amay J. Khalifeh, Jawad Yan, Ying Kim, Hojun Pezhouh, Maryam Kherad Doty, Karen Lee, Geumbee Chen, Yu-Yu Lee, Seung Min D’Andrea, Dominic Jung, Kimin Lee, KunHyuck Li, Kan Jo, Seongbin Wang, Heling Kim, Jae-Hwan Kim, Jeonghyun Choi, Sung-Geun Jang, Woo Jin Oh, Yong Suk Park, Inkyu Kwak, Sung Soo Park, Ji-Hyeon Hong, Doosun Feng, Xue Lee, Chi-Hwan Banks, Anthony Leal, Cecilia Lee, Hyuck Mo Huang, Yonggang Franz, Colin K. Ray, Wilson Z. MacEwan, Matthew Kang, Seung-Kyun Rogers, John A. Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion |
title | Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion |
title_full | Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion |
title_fullStr | Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion |
title_full_unstemmed | Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion |
title_short | Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion |
title_sort | wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455185/ https://www.ncbi.nlm.nih.gov/pubmed/32923633 http://dx.doi.org/10.1126/sciadv.abb1093 |
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