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Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain

Limited information is available regarding SARS-CoV-2 infections in children with underlying diseases. A retrospective study of children less than 15 years old with primary or secondary immunosuppression infected with SARS-CoV-2 during March 2020 was performed. In this series, 8 immunocompromised pa...

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Autores principales: Pérez-Martinez, Antonio, Guerra-García, Pilar, Melgosa, Marta, Frauca, Esteban, Fernandez-Camblor, Carlota, Remesal, Agustin, Calvo, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455510/
https://www.ncbi.nlm.nih.gov/pubmed/32860101
http://dx.doi.org/10.1007/s00431-020-03793-3
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author Pérez-Martinez, Antonio
Guerra-García, Pilar
Melgosa, Marta
Frauca, Esteban
Fernandez-Camblor, Carlota
Remesal, Agustin
Calvo, Cristina
author_facet Pérez-Martinez, Antonio
Guerra-García, Pilar
Melgosa, Marta
Frauca, Esteban
Fernandez-Camblor, Carlota
Remesal, Agustin
Calvo, Cristina
author_sort Pérez-Martinez, Antonio
collection PubMed
description Limited information is available regarding SARS-CoV-2 infections in children with underlying diseases. A retrospective study of children less than 15 years old with primary or secondary immunosuppression infected with SARS-CoV-2 during March 2020 was performed. In this series, 8 immunocompromised patients with COVID-19 disease are reported, accounting for 15% of the positive cases detected in children in a reference hospital. The severity of the symptoms was mild-moderate in the majority with a predominance of febrile syndrome, with mild radiological involvement and in some cases with mild respiratory distress that required oxygen therapy. The rational and prudent management of these patients is discussed, evaluating possible treatments and options for hospitalization or outpatient follow-up. Conclusion: In our experience, monitoring of children with immunosuppression and COVID-19 disease can be performed as outpatients if close monitoring is possible. Hospitalization should be assessed when high fever, radiological involvement, and/or respiratory distress are present.
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spelling pubmed-74555102020-08-31 Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain Pérez-Martinez, Antonio Guerra-García, Pilar Melgosa, Marta Frauca, Esteban Fernandez-Camblor, Carlota Remesal, Agustin Calvo, Cristina Eur J Pediatr Short Communication Limited information is available regarding SARS-CoV-2 infections in children with underlying diseases. A retrospective study of children less than 15 years old with primary or secondary immunosuppression infected with SARS-CoV-2 during March 2020 was performed. In this series, 8 immunocompromised patients with COVID-19 disease are reported, accounting for 15% of the positive cases detected in children in a reference hospital. The severity of the symptoms was mild-moderate in the majority with a predominance of febrile syndrome, with mild radiological involvement and in some cases with mild respiratory distress that required oxygen therapy. The rational and prudent management of these patients is discussed, evaluating possible treatments and options for hospitalization or outpatient follow-up. Conclusion: In our experience, monitoring of children with immunosuppression and COVID-19 disease can be performed as outpatients if close monitoring is possible. Hospitalization should be assessed when high fever, radiological involvement, and/or respiratory distress are present. Springer Berlin Heidelberg 2020-08-29 2021 /pmc/articles/PMC7455510/ /pubmed/32860101 http://dx.doi.org/10.1007/s00431-020-03793-3 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Short Communication
Pérez-Martinez, Antonio
Guerra-García, Pilar
Melgosa, Marta
Frauca, Esteban
Fernandez-Camblor, Carlota
Remesal, Agustin
Calvo, Cristina
Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain
title Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain
title_full Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain
title_fullStr Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain
title_full_unstemmed Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain
title_short Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain
title_sort clinical outcome of sars-cov-2 infection in immunosuppressed children in spain
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455510/
https://www.ncbi.nlm.nih.gov/pubmed/32860101
http://dx.doi.org/10.1007/s00431-020-03793-3
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