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XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition
Persistent R-loops (RNA–DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5′-3′-exoribonuclease 2 (XRN2) degrades RNA to resolve R-loops and promotes transcription termination. Previously, XRN2 was implicated in DNA double strand break (DSB) rep...
Autores principales: | Patidar, Praveen L., Viera, Talysa, Morales, Julio C., Singh, Naveen, Motea, Edward A., Khandelwal, Megha, Fattah, Farjana J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455564/ https://www.ncbi.nlm.nih.gov/pubmed/32859985 http://dx.doi.org/10.1038/s41598-020-71203-7 |
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