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Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients
Upper respiratory tract is the primary site of SARS-CoV-2 replication. Releasing of pro and anti-inflammatory mediators plays an important role in the immunopathogenesis of Coronavirus Disease 2019 (COVID-19). The aim of this study was to evaluate the early inflammatory response in upper airway by m...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455570/ https://www.ncbi.nlm.nih.gov/pubmed/32866645 http://dx.doi.org/10.1016/j.clim.2020.108576 |
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author | Montalvo Villalba, María Caridad Valdés Ramírez, Odalys Muné Jiménez, Mayra Arencibia Garcia, Amely Martinez Alfonso, Javier González Baéz, Guelsy Roque Arrieta, Rosmery Rosell Simón, Dianelvys Alvárez Gainza, Delmis Sierra Vázquez, Beatriz Resik Aguirre, Sonia Guzmán Tirado, Maria Guadalupe |
author_facet | Montalvo Villalba, María Caridad Valdés Ramírez, Odalys Muné Jiménez, Mayra Arencibia Garcia, Amely Martinez Alfonso, Javier González Baéz, Guelsy Roque Arrieta, Rosmery Rosell Simón, Dianelvys Alvárez Gainza, Delmis Sierra Vázquez, Beatriz Resik Aguirre, Sonia Guzmán Tirado, Maria Guadalupe |
author_sort | Montalvo Villalba, María Caridad |
collection | PubMed |
description | Upper respiratory tract is the primary site of SARS-CoV-2 replication. Releasing of pro and anti-inflammatory mediators plays an important role in the immunopathogenesis of Coronavirus Disease 2019 (COVID-19). The aim of this study was to evaluate the early inflammatory response in upper airway by measuring of IFN-γ, TGF-β1 and RANTES at mRNA level. Forty five SARS-CoV-2 infected patients were enrolled, whose were divided in two groups: asymptomatic and symptomatic. Twenty healthy persons, SARS-CoV-2 negative were included as controls. Higher IFN-γ expression was detected in SARS-CoV-2 infected patients in comparison with controls (p = 0.0393). IFN-γ expression was increased in symptomatic patients (p = 0.0405). TGF-β1 and RANTES expressions were lower in SARS-CoV-2 infected patients than controls (p < 0.0001; p = 0.0011, respectively). A significant correlation between IFN-γ and TGF-β1 was observed in SARS-CoV-2 asymptomatic patients (r = +0.61, p = 0.0014). The findings suggest that imbalance between IFN-γ and TGF-β1 expression could be an impact in clinical expression of SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-7455570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74555702020-08-31 Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients Montalvo Villalba, María Caridad Valdés Ramírez, Odalys Muné Jiménez, Mayra Arencibia Garcia, Amely Martinez Alfonso, Javier González Baéz, Guelsy Roque Arrieta, Rosmery Rosell Simón, Dianelvys Alvárez Gainza, Delmis Sierra Vázquez, Beatriz Resik Aguirre, Sonia Guzmán Tirado, Maria Guadalupe Clin Immunol Article Upper respiratory tract is the primary site of SARS-CoV-2 replication. Releasing of pro and anti-inflammatory mediators plays an important role in the immunopathogenesis of Coronavirus Disease 2019 (COVID-19). The aim of this study was to evaluate the early inflammatory response in upper airway by measuring of IFN-γ, TGF-β1 and RANTES at mRNA level. Forty five SARS-CoV-2 infected patients were enrolled, whose were divided in two groups: asymptomatic and symptomatic. Twenty healthy persons, SARS-CoV-2 negative were included as controls. Higher IFN-γ expression was detected in SARS-CoV-2 infected patients in comparison with controls (p = 0.0393). IFN-γ expression was increased in symptomatic patients (p = 0.0405). TGF-β1 and RANTES expressions were lower in SARS-CoV-2 infected patients than controls (p < 0.0001; p = 0.0011, respectively). A significant correlation between IFN-γ and TGF-β1 was observed in SARS-CoV-2 asymptomatic patients (r = +0.61, p = 0.0014). The findings suggest that imbalance between IFN-γ and TGF-β1 expression could be an impact in clinical expression of SARS-CoV-2 infection. Elsevier Inc. 2020-11 2020-08-29 /pmc/articles/PMC7455570/ /pubmed/32866645 http://dx.doi.org/10.1016/j.clim.2020.108576 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Montalvo Villalba, María Caridad Valdés Ramírez, Odalys Muné Jiménez, Mayra Arencibia Garcia, Amely Martinez Alfonso, Javier González Baéz, Guelsy Roque Arrieta, Rosmery Rosell Simón, Dianelvys Alvárez Gainza, Delmis Sierra Vázquez, Beatriz Resik Aguirre, Sonia Guzmán Tirado, Maria Guadalupe Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients |
title | Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients |
title_full | Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients |
title_fullStr | Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients |
title_full_unstemmed | Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients |
title_short | Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients |
title_sort | interferon gamma, tgf-β1 and rantes expression in upper airway samples from sars-cov-2 infected patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455570/ https://www.ncbi.nlm.nih.gov/pubmed/32866645 http://dx.doi.org/10.1016/j.clim.2020.108576 |
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