Intracellular sodium elevation reprograms cardiac metabolism

Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodelling occurs. Here, we assess whether acute (75 μM ouabain 100 nM blebbistatin) or chronic myocardial Na(i) load (PLM(3SA) mouse) are causally linked to metabolic remodelling and whether...

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Detalles Bibliográficos
Autores principales: Aksentijević, Dunja, Karlstaedt, Anja, Basalay, Marina V., O’Brien, Brett A., Sanchez-Tatay, David, Eminaga, Seda, Thakker, Alpesh, Tennant, Daniel A., Fuller, William, Eykyn, Thomas R., Taegtmeyer, Heinrich, Shattock, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455741/
https://www.ncbi.nlm.nih.gov/pubmed/32859897
http://dx.doi.org/10.1038/s41467-020-18160-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455741/
https://www.ncbi.nlm.nih.gov/pubmed/32859897
http://dx.doi.org/10.1038/s41467-020-18160-x

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