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Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice

The increasing prevalence of obesity and its effects on our society warrant intensifying basic animal research for understanding why habitual intake of highly palatable foods has increased due to recent global environmental changes. Here, we report that pregnant mice that consume a diet high in omeg...

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Autores principales: Sakayori, Nobuyuki, Katakura, Masanori, Hamazaki, Kei, Higuchi, Oki, Fujii, Kazuki, Fukabori, Ryoji, Iguchi, Yoshio, Setogawa, Susumu, Takao, Keizo, Miyazawa, Teruo, Arita, Makoto, Kobayashi, Kazuto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455742/
https://www.ncbi.nlm.nih.gov/pubmed/32859990
http://dx.doi.org/10.1038/s42003-020-01209-4
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author Sakayori, Nobuyuki
Katakura, Masanori
Hamazaki, Kei
Higuchi, Oki
Fujii, Kazuki
Fukabori, Ryoji
Iguchi, Yoshio
Setogawa, Susumu
Takao, Keizo
Miyazawa, Teruo
Arita, Makoto
Kobayashi, Kazuto
author_facet Sakayori, Nobuyuki
Katakura, Masanori
Hamazaki, Kei
Higuchi, Oki
Fujii, Kazuki
Fukabori, Ryoji
Iguchi, Yoshio
Setogawa, Susumu
Takao, Keizo
Miyazawa, Teruo
Arita, Makoto
Kobayashi, Kazuto
author_sort Sakayori, Nobuyuki
collection PubMed
description The increasing prevalence of obesity and its effects on our society warrant intensifying basic animal research for understanding why habitual intake of highly palatable foods has increased due to recent global environmental changes. Here, we report that pregnant mice that consume a diet high in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and low in omega-3 (n-3) PUFAs (an n-6(high)/n-3(low) diet), whose n-6/n-3 ratio is approximately 120, induces hedonic consumption in the offspring by upregulating the midbrain dopaminergic system. We found that exposure to the n-6(high)/n-3(low) diet specifically increases the consumption of palatable foods via increased mesolimbic dopamine release. In addition, neurodevelopmental analyses revealed that this induced hedonic consumption is programmed during embryogenesis, as dopaminergic neurogenesis is increased during in utero access to the n-6(high)/n-3(low) diet. Our findings reveal that maternal consumption of PUFAs can have long-lasting effects on the offspring’s pattern for consuming highly palatable foods.
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spelling pubmed-74557422020-09-03 Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice Sakayori, Nobuyuki Katakura, Masanori Hamazaki, Kei Higuchi, Oki Fujii, Kazuki Fukabori, Ryoji Iguchi, Yoshio Setogawa, Susumu Takao, Keizo Miyazawa, Teruo Arita, Makoto Kobayashi, Kazuto Commun Biol Article The increasing prevalence of obesity and its effects on our society warrant intensifying basic animal research for understanding why habitual intake of highly palatable foods has increased due to recent global environmental changes. Here, we report that pregnant mice that consume a diet high in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and low in omega-3 (n-3) PUFAs (an n-6(high)/n-3(low) diet), whose n-6/n-3 ratio is approximately 120, induces hedonic consumption in the offspring by upregulating the midbrain dopaminergic system. We found that exposure to the n-6(high)/n-3(low) diet specifically increases the consumption of palatable foods via increased mesolimbic dopamine release. In addition, neurodevelopmental analyses revealed that this induced hedonic consumption is programmed during embryogenesis, as dopaminergic neurogenesis is increased during in utero access to the n-6(high)/n-3(low) diet. Our findings reveal that maternal consumption of PUFAs can have long-lasting effects on the offspring’s pattern for consuming highly palatable foods. Nature Publishing Group UK 2020-08-28 /pmc/articles/PMC7455742/ /pubmed/32859990 http://dx.doi.org/10.1038/s42003-020-01209-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sakayori, Nobuyuki
Katakura, Masanori
Hamazaki, Kei
Higuchi, Oki
Fujii, Kazuki
Fukabori, Ryoji
Iguchi, Yoshio
Setogawa, Susumu
Takao, Keizo
Miyazawa, Teruo
Arita, Makoto
Kobayashi, Kazuto
Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice
title Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice
title_full Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice
title_fullStr Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice
title_full_unstemmed Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice
title_short Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice
title_sort maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455742/
https://www.ncbi.nlm.nih.gov/pubmed/32859990
http://dx.doi.org/10.1038/s42003-020-01209-4
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