Sex differences in oncogenic mutational processes

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here w...

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Autores principales: Li, Constance H., Prokopec, Stephenie D., Sun, Ren X., Yousif, Fouad, Schmitz, Nathaniel, Boutros, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455744/
https://www.ncbi.nlm.nih.gov/pubmed/32859912
http://dx.doi.org/10.1038/s41467-020-17359-2
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author Li, Constance H.
Prokopec, Stephenie D.
Sun, Ren X.
Yousif, Fouad
Schmitz, Nathaniel
Boutros, Paul C.
author_facet Li, Constance H.
Prokopec, Stephenie D.
Sun, Ren X.
Yousif, Fouad
Schmitz, Nathaniel
Boutros, Paul C.
author_sort Li, Constance H.
collection PubMed
description Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.
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spelling pubmed-74557442020-09-04 Sex differences in oncogenic mutational processes Li, Constance H. Prokopec, Stephenie D. Sun, Ren X. Yousif, Fouad Schmitz, Nathaniel Boutros, Paul C. Nat Commun Article Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research. Nature Publishing Group UK 2020-08-28 /pmc/articles/PMC7455744/ /pubmed/32859912 http://dx.doi.org/10.1038/s41467-020-17359-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Constance H.
Prokopec, Stephenie D.
Sun, Ren X.
Yousif, Fouad
Schmitz, Nathaniel
Boutros, Paul C.
Sex differences in oncogenic mutational processes
title Sex differences in oncogenic mutational processes
title_full Sex differences in oncogenic mutational processes
title_fullStr Sex differences in oncogenic mutational processes
title_full_unstemmed Sex differences in oncogenic mutational processes
title_short Sex differences in oncogenic mutational processes
title_sort sex differences in oncogenic mutational processes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455744/
https://www.ncbi.nlm.nih.gov/pubmed/32859912
http://dx.doi.org/10.1038/s41467-020-17359-2
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