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Inhibition of PI3K-AKT Signaling Blocks PGE(2)-Induced COX-2 Expression in Lung Adenocarcinoma

PURPOSE: Cyclooxygenase-2 (COX-2) and its enzymatic product prostaglandin E2 (PGE(2)) possess tumor-promoting activity, and COX-2 is considered as a candidate for targeted cancer therapy. However, several randomized clinical trials using COX-2 inhibitors to treat advanced lung cancer have failed to...

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Detalles Bibliográficos
Autores principales:	Yang, Jianjian, Wang, Xue, Gao, Yi, Fang, Can, Ye, Fan, Huang, Bing, Li, Lequn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455753/ https://www.ncbi.nlm.nih.gov/pubmed/32904445 http://dx.doi.org/10.2147/OTT.S263977

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