The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8(+) T cells

Cytotoxic T cell differentiation is guided by epigenome adaptations, but how epigenetic mechanisms control lymphocyte development has not been well defined. Here we show that the histone methyltransferase DOT1L, which marks the nucleosome core on active genes, safeguards normal differentiation of CD...

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Detalles Bibliográficos
Autores principales: Kwesi-Maliepaard, Eliza Mari, Aslam, Muhammad Assad, Alemdehy, Mir Farshid, van den Brand, Teun, McLean, Chelsea, Vlaming, Hanneke, van Welsem, Tibor, Korthout, Tessy, Lancini, Cesare, Hendriks, Sjoerd, Ahrends, Tomasz, van Dinther, Dieke, den Haan, Joke M. M., Borst, Jannie, de Wit, Elzo, van Leeuwen, Fred, Jacobs, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456197/
https://www.ncbi.nlm.nih.gov/pubmed/32764145
http://dx.doi.org/10.1073/pnas.1920372117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456197/
https://www.ncbi.nlm.nih.gov/pubmed/32764145
http://dx.doi.org/10.1073/pnas.1920372117

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