Cargando…
Evaluation of the rate of COVID-19 infection, hospitalization and death among Iranian patients with multiple sclerosis
BACKGROUND: COVID-19 is increasingly expanding all over the world. People who have an underlying disease or taking immunosuppressive drugs are generally more likely to be infected than the others. Multiple sclerosis (MS) patients may also be at risk of the disease and its complications depending on...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456295/ https://www.ncbi.nlm.nih.gov/pubmed/32890817 http://dx.doi.org/10.1016/j.msard.2020.102472 |
_version_ | 1783575772254961664 |
---|---|
author | Sahraian, Mohammad Ali Azimi, Amirreza Navardi, Samira Ala, Sara Naser Moghadasi, Abdorreza |
author_facet | Sahraian, Mohammad Ali Azimi, Amirreza Navardi, Samira Ala, Sara Naser Moghadasi, Abdorreza |
author_sort | Sahraian, Mohammad Ali |
collection | PubMed |
description | BACKGROUND: COVID-19 is increasingly expanding all over the world. People who have an underlying disease or taking immunosuppressive drugs are generally more likely to be infected than the others. Multiple sclerosis (MS) patients may also be at risk of the disease and its complications depending on the medication they are taking. In this study, we evaluated a large population of patients with MS with different disease modifying drugs to show if any of them increases the risk. In addition, this study evaluates the incidence of COVID-19 in patients with MS, the rate of hospitalization or death in these patients. METHOD: This study was performed at the MS Clinic of Sina Hospital. All patients were contacted and their demographic characteristics were recorded. They were then asked about their COVID-19 symptoms. Patients with these symptoms were further evaluated. The documents were reviewed by treating neurologist and MS nurses to be sure about diagnosis of COVID19. The positive polymerase chain reaction (PCR) result or compatible lung computed tomography (CT) scan was acceptable for COVID-19 diagnosis. RESULTS: 4647 patients answered the phone contact. Of these, 68 were infected with the COVID-19. The rate of hospitalization was 25% which is far more than general population. Two patients died from COVID-19. Rituximab was associated with increase rate of COVID-19 infection but not with hospitalization rate. There was no significant correlation between use of other drugs and rate of infection. CONCLUSION: This study revealed that the incidence of COVID-19 in MS patients is not more than general population, but the risk of hospitalization in these patients is higher than estimated for the disease. This highlights the importance of communicating to patients the severity of COVID-19 and the importance of risk reduction behaviors like social distancing and mask use. |
format | Online Article Text |
id | pubmed-7456295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74562952020-08-31 Evaluation of the rate of COVID-19 infection, hospitalization and death among Iranian patients with multiple sclerosis Sahraian, Mohammad Ali Azimi, Amirreza Navardi, Samira Ala, Sara Naser Moghadasi, Abdorreza Mult Scler Relat Disord Original Article BACKGROUND: COVID-19 is increasingly expanding all over the world. People who have an underlying disease or taking immunosuppressive drugs are generally more likely to be infected than the others. Multiple sclerosis (MS) patients may also be at risk of the disease and its complications depending on the medication they are taking. In this study, we evaluated a large population of patients with MS with different disease modifying drugs to show if any of them increases the risk. In addition, this study evaluates the incidence of COVID-19 in patients with MS, the rate of hospitalization or death in these patients. METHOD: This study was performed at the MS Clinic of Sina Hospital. All patients were contacted and their demographic characteristics were recorded. They were then asked about their COVID-19 symptoms. Patients with these symptoms were further evaluated. The documents were reviewed by treating neurologist and MS nurses to be sure about diagnosis of COVID19. The positive polymerase chain reaction (PCR) result or compatible lung computed tomography (CT) scan was acceptable for COVID-19 diagnosis. RESULTS: 4647 patients answered the phone contact. Of these, 68 were infected with the COVID-19. The rate of hospitalization was 25% which is far more than general population. Two patients died from COVID-19. Rituximab was associated with increase rate of COVID-19 infection but not with hospitalization rate. There was no significant correlation between use of other drugs and rate of infection. CONCLUSION: This study revealed that the incidence of COVID-19 in MS patients is not more than general population, but the risk of hospitalization in these patients is higher than estimated for the disease. This highlights the importance of communicating to patients the severity of COVID-19 and the importance of risk reduction behaviors like social distancing and mask use. Elsevier B.V. 2020-11 2020-08-29 /pmc/articles/PMC7456295/ /pubmed/32890817 http://dx.doi.org/10.1016/j.msard.2020.102472 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Sahraian, Mohammad Ali Azimi, Amirreza Navardi, Samira Ala, Sara Naser Moghadasi, Abdorreza Evaluation of the rate of COVID-19 infection, hospitalization and death among Iranian patients with multiple sclerosis |
title | Evaluation of the rate of COVID-19 infection, hospitalization and death among Iranian patients with multiple sclerosis |
title_full | Evaluation of the rate of COVID-19 infection, hospitalization and death among Iranian patients with multiple sclerosis |
title_fullStr | Evaluation of the rate of COVID-19 infection, hospitalization and death among Iranian patients with multiple sclerosis |
title_full_unstemmed | Evaluation of the rate of COVID-19 infection, hospitalization and death among Iranian patients with multiple sclerosis |
title_short | Evaluation of the rate of COVID-19 infection, hospitalization and death among Iranian patients with multiple sclerosis |
title_sort | evaluation of the rate of covid-19 infection, hospitalization and death among iranian patients with multiple sclerosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456295/ https://www.ncbi.nlm.nih.gov/pubmed/32890817 http://dx.doi.org/10.1016/j.msard.2020.102472 |
work_keys_str_mv | AT sahraianmohammadali evaluationoftherateofcovid19infectionhospitalizationanddeathamongiranianpatientswithmultiplesclerosis AT azimiamirreza evaluationoftherateofcovid19infectionhospitalizationanddeathamongiranianpatientswithmultiplesclerosis AT navardisamira evaluationoftherateofcovid19infectionhospitalizationanddeathamongiranianpatientswithmultiplesclerosis AT alasara evaluationoftherateofcovid19infectionhospitalizationanddeathamongiranianpatientswithmultiplesclerosis AT nasermoghadasiabdorreza evaluationoftherateofcovid19infectionhospitalizationanddeathamongiranianpatientswithmultiplesclerosis |