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Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives

PURPOSE: Adequate clinical services have yet to be established in the majority of African countries, where childhood cancer survival rates vary from 8.1% to 30.3%. The aim of this review is to describe the landscape of pediatric oncology trials in Africa, identify challenges, and offer future opport...

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Autores principales: van Heerden, Jaques, Zaghloul, Mohamed, Neven, Anouk, de Rojas, Teresa, Geel, Jennifer, Patte, Catherine, Balagadde-Kambugu, Joyce, Hesseling, Peter, Tchintseme, Francine, Bouffet, Eric, Hessissen, Laila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456323/
https://www.ncbi.nlm.nih.gov/pubmed/32762563
http://dx.doi.org/10.1200/GO.20.00159
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author van Heerden, Jaques
Zaghloul, Mohamed
Neven, Anouk
de Rojas, Teresa
Geel, Jennifer
Patte, Catherine
Balagadde-Kambugu, Joyce
Hesseling, Peter
Tchintseme, Francine
Bouffet, Eric
Hessissen, Laila
author_facet van Heerden, Jaques
Zaghloul, Mohamed
Neven, Anouk
de Rojas, Teresa
Geel, Jennifer
Patte, Catherine
Balagadde-Kambugu, Joyce
Hesseling, Peter
Tchintseme, Francine
Bouffet, Eric
Hessissen, Laila
author_sort van Heerden, Jaques
collection PubMed
description PURPOSE: Adequate clinical services have yet to be established in the majority of African countries, where childhood cancer survival rates vary from 8.1% to 30.3%. The aim of this review is to describe the landscape of pediatric oncology trials in Africa, identify challenges, and offer future opportunities for research collaborations. METHODS: The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials.gov, and a literature overview of publications on the subject of pediatric oncology clinical research supported by expert opinions on the current situation and challenges. RESULTS: The SIOP global mapping survey received responses from 47 of 54 African countries, of which 23 have active clinical research programs. A preliminary search of ClinicalTrials.gov showed that only 105 (12.1%) of 868 African oncology studies included children and adolescents. Of these, 53 (50.5%) were interventional trials according to the registry’s classification. The small number of African trials for children and adolescents included palliative care and leukemia trials. In African oncology journals and international pediatric oncology journals, < 1% of the pediatric oncology publications come from Africa. Services and research were strengthened by international collaboration. National studies focused on clinical needs, local challenges, or interventional priorities. Both the literature review and the expert opinions highlight the need to expand clinical research in Africa, despite ongoing regional instability and lack of resources. CONCLUSION: While a low number of pediatric clinical treatment trials are open to African children and adolescents, clinical research of high quality is being done in Africa. Several initiatives are stimulating the development of the research capacity across the continent, which should increase the publication output.
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spelling pubmed-74563232020-10-05 Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives van Heerden, Jaques Zaghloul, Mohamed Neven, Anouk de Rojas, Teresa Geel, Jennifer Patte, Catherine Balagadde-Kambugu, Joyce Hesseling, Peter Tchintseme, Francine Bouffet, Eric Hessissen, Laila JCO Glob Oncol REVIEW ARTICLES PURPOSE: Adequate clinical services have yet to be established in the majority of African countries, where childhood cancer survival rates vary from 8.1% to 30.3%. The aim of this review is to describe the landscape of pediatric oncology trials in Africa, identify challenges, and offer future opportunities for research collaborations. METHODS: The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials.gov, and a literature overview of publications on the subject of pediatric oncology clinical research supported by expert opinions on the current situation and challenges. RESULTS: The SIOP global mapping survey received responses from 47 of 54 African countries, of which 23 have active clinical research programs. A preliminary search of ClinicalTrials.gov showed that only 105 (12.1%) of 868 African oncology studies included children and adolescents. Of these, 53 (50.5%) were interventional trials according to the registry’s classification. The small number of African trials for children and adolescents included palliative care and leukemia trials. In African oncology journals and international pediatric oncology journals, < 1% of the pediatric oncology publications come from Africa. Services and research were strengthened by international collaboration. National studies focused on clinical needs, local challenges, or interventional priorities. Both the literature review and the expert opinions highlight the need to expand clinical research in Africa, despite ongoing regional instability and lack of resources. CONCLUSION: While a low number of pediatric clinical treatment trials are open to African children and adolescents, clinical research of high quality is being done in Africa. Several initiatives are stimulating the development of the research capacity across the continent, which should increase the publication output. American Society of Clinical Oncology 2020-08-07 /pmc/articles/PMC7456323/ /pubmed/32762563 http://dx.doi.org/10.1200/GO.20.00159 Text en © 2020 by American Society of Clinical Oncology https://creativecommons.org/licenses/by-nc-nd/4.0/ Creative Commons Attribution Non-Commercial No Derivatives 4.0 License: https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle REVIEW ARTICLES
van Heerden, Jaques
Zaghloul, Mohamed
Neven, Anouk
de Rojas, Teresa
Geel, Jennifer
Patte, Catherine
Balagadde-Kambugu, Joyce
Hesseling, Peter
Tchintseme, Francine
Bouffet, Eric
Hessissen, Laila
Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives
title Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives
title_full Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives
title_fullStr Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives
title_full_unstemmed Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives
title_short Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives
title_sort pediatric oncology clinical trials and collaborative research in africa: current landscape and future perspectives
topic REVIEW ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456323/
https://www.ncbi.nlm.nih.gov/pubmed/32762563
http://dx.doi.org/10.1200/GO.20.00159
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