Cargando…

Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism

Gut microbial and metabolite alterations have been linked to the pathogenesis of inflammatory bowel diseases. Here we perform a multi-omics microbiome and metabolite analysis of a longitudinal cohort of Crohn’s disease patients undergoing autologous hematopoietic stem cell transplantation, and inves...

Descripción completa

Detalles Bibliográficos
Autores principales:	Metwaly, Amira, Dunkel, Andreas, Waldschmitt, Nadine, Raj, Abilash Chakravarthy Durai, Lagkouvardos, Ilias, Corraliza, Ana Maria, Mayorgas, Aida, Martinez-Medina, Margarita, Reiter, Sinah, Schloter, Michael, Hofmann, Thomas, Allez, Matthieu, Panes, Julian, Salas, Azucena, Haller, Dirk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456324/ https://www.ncbi.nlm.nih.gov/pubmed/32859898 http://dx.doi.org/10.1038/s41467-020-17956-1

Ejemplares similares

Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn’s disease
por: Metwaly, Amira, et al.
Publicado: (2023)

Multi-omic modelling of inflammatory bowel disease with regularized canonical correlation analysis
por: Revilla, Lluís, et al.
Publicado: (2021)

Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn’s disease recurrence
por: Khaloian, Sevana, et al.
Publicado: (2020)

Differences in Peripheral and Tissue Immune Cell Populations Following Haematopoietic Stem Cell Transplantation in Crohn’s Disease Patients
por: Corraliza, Ana M, et al.
Publicado: (2019)

Generation of human colon organoids from healthy and inflammatory bowel disease mucosa
por: Dotti, Isabella, et al.
Publicado: (2022)

Intestinal Inflammation Modulates the Epithelial Response to Butyrate in Patients With Inflammatory Bowel Disease
por: Ferrer-Picón, Elena, et al.
Publicado: (2020)

A Novel Strategy to Study the Invasive Capability of Adherent-Invasive Escherichia coli by Using Human Primary Organoid-Derived Epithelial Monolayers
por: Mayorgas, Aida, et al.
Publicado: (2021)

TNF ( ΔARE ) Pigs: A Translational Crohn’s Disease Model
por: Winogrodzki, Thomas, et al.
Publicado: (2023)

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence
por: Schaubeck, Monika, et al.
Publicado: (2016)

Microbial Signals Link Westernized Diet to Metabolic Inflammation: More Evidence to Resolve Controversies
por: Metwaly, Amira, et al.
Publicado: (2019)

Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn’s disease
por: Alfaro, Ignacio, et al.
Publicado: (2019)

MiMiC: a bioinformatic approach for generation of synthetic communities from metagenomes
por: Kumar, Neeraj, et al.
Publicado: (2021)

DivCom: A Tool for Systematic Partition of Groups of Microbial Profiles Into Intrinsic Subclusters and Distance-Based Subgroup Comparisons
por: Intze , Evangelia, et al.
Publicado: (2022)

Randomized Controlled Trial Substudy of Cell-specific Mechanisms of Janus Kinase 1 Inhibition With Upadacitinib in the Crohn’s Disease Intestinal Mucosa: Analysis From the CELEST Study
por: Aguilar, Daniel, et al.
Publicado: (2021)

Modeling microbiota-associated human diseases: from minimal models to complex systems
por: Aguanno, Doriane, et al.
Publicado: (2022)

Cephalic Duodenopancreatectomy for Hyperalgic Duodenal Crohn's Disease Fistulized in the Pancreatic Gland
por: Guellouz, Sabra, et al.
Publicado: (2014)

Selective IL-23 Inhibition by Risankizumab Modulates the Molecular Profile in the Colon and Ileum of Patients With Active Crohn’s Disease: Results From a Randomised Phase II Biopsy Sub-study
por: Visvanathan, Sudha, et al.
Publicado: (2018)

IMNGS: A comprehensive open resource of processed 16S rRNA microbial profiles for ecology and diversity studies
por: Lagkouvardos, Ilias, et al.
Publicado: (2016)

Comparison of the Efficacy of the Various Treatment Modalities in the Management of Perianal Crohn’s Fistula: A Review
por: Feroz, Shah Huzaifa, et al.
Publicado: (2020)

Is Autologous Fecal Microbiota Transfer after Exclusive Enteral Nutrition in Pediatric Crohn’s Disease Patients Rational and Feasible? Data from a Feasibility Test
por: Hoelz, Hannes, et al.
Publicado: (2023)

Dissecting Common and Unique Effects of Anti-α4β7 and Anti-Tumor Necrosis Factor Treatment in Ulcerative Colitis
por: Veny, Marisol, et al.
Publicado: (2020)

An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients
por: Bassolas-Molina, Helena, et al.
Publicado: (2018)

An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome
por: Lesker, Till R., et al.
Publicado: (2020)

Rhea: a transparent and modular R pipeline for microbial profiling based on 16S rRNA gene amplicons
por: Lagkouvardos, Ilias, et al.
Publicado: (2017)

Taxonomy Informed Clustering, an Optimized Method for Purer and More Informative Clusters in Diversity Analysis and Microbiome Profiling
por: Kioukis, Antonios, et al.
Publicado: (2022)

Cronos: A Machine Learning Pipeline for Description and Predictive Modeling of Microbial Communities Over Time
por: Litos, Aristeidis, et al.
Publicado: (2022)

Structural robustness of the gut mucosal microbiota is associated with Crohn's disease remission after surgery
por: Mondot, S, et al.
Publicado: (2016)

Large-Scale Integration of Amplicon Data Reveals Massive Diversity within Saprospirales, Mostly Originating from Saline Environments
por: Mourgela, Rafaila Nikola, et al.
Publicado: (2023)

Prevalence of Yersinia Species in the Ileum of Crohn's Disease Patients and Controls
por: Le Baut, Guillaume, et al.
Publicado: (2018)

The giant ciliate Zoothamnium niveum and its thiotrophic epibiont Candidatus Thiobios zoothamnicoli: a model system to study interspecies cooperation
por: Bright, Monika, et al.
Publicado: (2014)

Pre-digest of unprotected DNA by Benzonase improves the representation of living skin bacteria and efficiently depletes host DNA
por: Amar, Yacine, et al.
Publicado: (2021)

Burden and outcomes for complex perianal fistulas in Crohn’s disease: Systematic review
por: Panes, Julian, et al.
Publicado: (2018)

Acute and delayed sulfur mustard toxicity; novel mechanisms and future studies
por: Korkmaz, Ahmet, et al.
Publicado: (2008)

Predictors of bowel damage in the long-term progression of Crohn’s disease
por: Fernández-Clotet, Agnes, et al.
Publicado: (2022)

Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women
por: Ott, Beate, et al.
Publicado: (2017)

Epigenetic master regulators HDAC1 and HDAC5 control pathobiont Enterobacteria colonization in ileal mucosa of Crohn’s disease patients
por: Chervy, Mélissa, et al.
Publicado: (2022)

KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease
por: Bottois, Hugo, et al.
Publicado: (2020)

Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome
por: Hartstra, Annick V., et al.
Publicado: (2020)

The “Crosstalk” between Microbiota and Metabolomic Profile of Kefalograviera Cheese after the Innovative Feeding Strategy of Dairy Sheep by Omega-3 Fatty Acids
por: Tzora, Athina, et al.
Publicado: (2022)

Life in an unusual intracellular niche: a bacterial symbiont infecting the nucleus of amoebae
por: Schulz, Frederik, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_dn2g5co2qfvke5bgd6r2dqa8bs